Erhan Gökçek1, Ayhan Kaydu2, Mehmet Salim Akdemir3, Ferit Akil4, Ibrahim Ozkan Akıncı5. 1. MD, Department of Aneaesthesiolgy, Diyarbakır Selahaddini Eyyubi State Hospital, Turkey. Intellectual, scientific and design of the study; acquisition and interpretation of data; manuscript writing. 2. MD, Department of Aneaesthesiolgy, Diyarbakır Selahaddini Eyyubi State Hospital, Turkey. Acquisition and interpretation of data, manuscript writing, critical revision. 3. MD, Department of Aneaesthesiolgy, İstanbul Umraniye Research and Education Hospital, Turkey. Design of the study, acquisition and interpretation of data. 4. MD, Department of Otorhinolaryngology, Diyarbakır Selahaddini Eyyubi State Hospital, Turkey. Acquisition and interpretation of data, statistical analysis. 5. Head, Division of Neuroanesthesia, Department of Aneaesthesiolgy, Faculty of Medicine, İstanbul University, Turkey. Intellectual and scientific content of the study, manuscript writing, critical revision.
Abstract
PURPOSE: : To compared the effects of sevoflurane and desflurane on early anesthesia recovery in patients undergoing to craniotomy for intracranial lesions. METHODS: : After IRB approval, the study included 50 patients aged 18-70 years who had ASA physical statuses of I-II and were scheduled for intracranial surgery. Patients were randomly divided into two groups: sevoflurane and desflurane. Anaesthesia was routinely induced in all patients followed by desflurane 5%-6% or sevoflurane 1%-2%. Moreover remifentanil infusion (0.05-0.2 mcg/kg/min) was adjusted to maintain mean arterial pressure (MAP) within 20% baseline and heart rate <90 bpm. Postoperatively, patients were evaluated over time for responses to painful stimulus, eye opening, hand squeezing, extubation, orientation and time required to achieve a Modified Aldrete Score of 9-10. Parametric and non-parametric data were assessed using Student's t- and Mann-Whitney U tests, respectively. A p<0.05 was taken as statistically significant. RESULTS: : The times to responses to painful stimuli (7.7±2.7 vs. 4.8±1.7 min.; p<0.001), emergence (9.5±2.81 vs. 6.3±2.2 min.; p<0.001), hand-squeezing (12.1±2.9 vs. 8.2±2.3 min.; p<0.001), extubation (10.1±2.87 vs. 7.1±1.6 min.; p<0.001), orientation (15.3±3.2 vs. 10.3±2.7 min.; p<0.001) and Aldrete score of 9-10 (23.3±6.1 vs. 15.8±3.8 min.; p<0.001) were significantly lower with desflurane-based anaesthesia vs. sevoflurane-based anaesthesia. CONCLUSION: : Desflurane yields early recovery functions and facilitates early postoperative neurologic examinations of intracranial surgery patients.
PURPOSE: : To compared the effects of sevoflurane and desflurane on early anesthesia recovery in patients undergoing to craniotomy for intracranial lesions. METHODS: : After IRB approval, the study included 50 patients aged 18-70 years who had ASA physical statuses of I-II and were scheduled for intracranial surgery. Patients were randomly divided into two groups: sevoflurane and desflurane. Anaesthesia was routinely induced in all patients followed by desflurane 5%-6% or sevoflurane 1%-2%. Moreover remifentanil infusion (0.05-0.2 mcg/kg/min) was adjusted to maintain mean arterial pressure (MAP) within 20% baseline and heart rate <90 bpm. Postoperatively, patients were evaluated over time for responses to painful stimulus, eye opening, hand squeezing, extubation, orientation and time required to achieve a Modified Aldrete Score of 9-10. Parametric and non-parametric data were assessed using Student's t- and Mann-Whitney U tests, respectively. A p<0.05 was taken as statistically significant. RESULTS: : The times to responses to painful stimuli (7.7±2.7 vs. 4.8±1.7 min.; p<0.001), emergence (9.5±2.81 vs. 6.3±2.2 min.; p<0.001), hand-squeezing (12.1±2.9 vs. 8.2±2.3 min.; p<0.001), extubation (10.1±2.87 vs. 7.1±1.6 min.; p<0.001), orientation (15.3±3.2 vs. 10.3±2.7 min.; p<0.001) and Aldrete score of 9-10 (23.3±6.1 vs. 15.8±3.8 min.; p<0.001) were significantly lower with desflurane-based anaesthesia vs. sevoflurane-based anaesthesia. CONCLUSION: : Desflurane yields early recovery functions and facilitates early postoperative neurologic examinations of intracranial surgery patients.