Literature DB >> 27736753

Gentamicin Susceptibility among a Sample of Multidrug-Resistant Neisseria gonorrhoeae Isolates in India.

Manju Bala1, Vikram Singh2,3, Aradhana Bhargava2, Monika Kakran2, Naveen Chandra Joshi2, Ravi Bhatnagar3.   

Abstract

Antimicrobial susceptibility testing of 258 Neisseria gonorrhoeae isolates by Etest determined that 60.1% were multidrug resistant (MDR), while 5% of the strains had decreased susceptibility to currently recommended extended-spectrum cephalosporins (ESCs). Among these, 84.5% of MDR strains and 76.9% of strains that had decreased susceptibility to ESCs were susceptible to gentamicin. No MDR isolate was resistant to gentamicin. These in vitro results suggest that gentamicin might be an effective treatment option for the MDR strains and in dual therapy for gonorrhea. However, further research regarding the clinical treatment outcomes is essential.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2016        PMID： 27736753      PMCID： PMC5119040          DOI： 10.1128/AAC.01907-16

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  21 in total

1.  Cephalosporin resistant Neisseria gonorrhoeae: time to consider gentamicin?

Authors:  J D C Ross; D A Lewis
Journal:  Sex Transm Infect       Date:  2012-02       Impact factor: 3.519

2.  The serious threat of multidrug-resistant and untreatable gonorrhoea: the pressing need for global action to control the spread of antimicrobial resistance, and mitigate the impact on sexual and reproductive health.

Authors:  Francis Ndowa; Manjula Lusti-Narasimhan; Magnus Unemo
Journal:  Sex Transm Infect       Date:  2012-08       Impact factor: 3.519

Review 3.  The ticking time bomb: escalating antibiotic resistance in Neisseria gonorrhoeae is a public health disaster in waiting.

Authors:  David M Whiley; Namraj Goire; Monica M Lahra; Basil Donovan; Athena E Limnios; Michael D Nissen; Theo P Sloots
Journal:  J Antimicrob Chemother       Date:  2012-05-17       Impact factor: 5.790

4.  Emergence of quinolone resistance and cephalosporin MIC creep in Neisseria gonorrhoeae isolates from a cohort of young men in Kisumu, Kenya, 2002 to 2009.

Authors:  Supriya D Mehta; Ian Maclean; Jeckoniah O Ndinya-Achola; Stephen Moses; Irene Martin; Allan Ronald; Lawrence Agunda; Ruth Murugu; Robert C Bailey; Johan Melendez; Jonathan M Zenilman
Journal:  Antimicrob Agents Chemother       Date:  2011-05-23       Impact factor: 5.191

5.  High-level cefixime- and ceftriaxone-resistant Neisseria gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failure.

Authors:  Magnus Unemo; Daniel Golparian; Robert Nicholas; Makoto Ohnishi; Anne Gallay; Patrice Sednaoui
Journal:  Antimicrob Agents Chemother       Date:  2011-12-12       Impact factor: 5.191

6.  Trends of resistance to antimicrobials recommended currently and in the past for management of gonorrhea in the Apex STD center in India and comparison of antimicrobial resistance profile between 2002-2006 and 2007-2012.

Authors:  Manju Bala; Vikram Singh; Aradhana Bhargava; V Ramesh
Journal:  Sex Transm Dis       Date:  2015-04       Impact factor: 2.830

7.  Susceptibility of Neisseria gonorrhoeae associated with pelvic inflammatory disease to cefoxitin, ceftriaxone, clindamycin, gentamicin, doxycycline, azithromycin, and other antimicrobial agents.

Authors:  R J Rice; J S Knapp
Journal:  Antimicrob Agents Chemother       Date:  1994-07       Impact factor: 5.191

8.  Trends in antimicrobial resistance in Neisseria gonorrhoeae in the USA: the Gonococcal Isolate Surveillance Project (GISP), January 2006-June 2012.

Authors:  Robert D Kirkcaldy; Sarah Kidd; Hillard S Weinstock; John R Papp; Gail A Bolan
Journal:  Sex Transm Infect       Date:  2013-12       Impact factor: 3.519

9.  Comparative assessment of CDS, CLSI disc diffusion and Etest techniques for antimicrobial susceptibility testing of Neisseria gonorrhoeae: a 6-year study.

Authors:  Vikram Singh; Manju Bala; Monika Kakran; V Ramesh
Journal:  BMJ Open       Date:  2012-07-02       Impact factor: 2.692

Review 10.  The effectiveness of gentamicin in the treatment of Neisseria gonorrhoeae: a systematic review.

Authors:  Emma Hathorn; Divya Dhasmana; Lelia Duley; Jonathan D C Ross
Journal:  Syst Rev       Date:  2014-09-19
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  7 in total

1.  Antimicrobial Susceptibility Testing Patterns of Neisseria gonorrhoeae from Patients Attending Sexually Transmitted Infections Clinics in Six Regions in Tanzania.

Authors:  Said Aboud; Simon N Buhalata; Onduru G Onduru; Mercy G Chiduo; Gideon P Kwesigabo; Stephen E Mshana; Alphaxard M Manjurano; Mansuet M Temu; Coleman Kishamawe; John M Changalucha
Journal:  Trop Med Infect Dis       Date:  2022-06-02

2.  A Single Amino Acid Substitution in Elongation Factor G Can Confer Low-Level Gentamicin Resistance in Neisseria gonorrhoeae.

Authors:  Concerta L Holley; Vijaya Dhulipala; Jacqueline T Balthazar; Adriana Le Van; Afrin A Begum; Shao-Chun Chen; Timothy D Read; Mitch Matoga; Irving F Hoffman; Daniel Golparian; Magnus Unemo; Ann E Jerse; William M Shafer
Journal:  Antimicrob Agents Chemother       Date:  2022-04-25       Impact factor: 5.938

3.  Evaluation of apramycin against spectinomycin-resistant and -susceptible strains of Neisseria gonorrhoeae.

Authors:  Stefan Riedel; Divya Vijayakumar; Gretchen Berg; Anthony D Kang; Kenneth P Smith; James E Kirby
Journal:  J Antimicrob Chemother       Date:  2019-05-01       Impact factor: 5.790

4.  In vitro efficacy of 21 dual antimicrobial combinations comprising novel and currently recommended combinations for treatment of drug resistant gonorrhoea in future era.

Authors:  Vikram Singh; Manju Bala; Aradhana Bhargava; Monika Kakran; Ravi Bhatnagar
Journal:  PLoS One       Date:  2018-03-06       Impact factor: 3.240

5.  Systematic review and survey of Neisseria gonorrhoeae ceftriaxone and azithromycin susceptibility data in the Asia Pacific, 2011 to 2016.

Authors:  C R Robert George; Rodney P Enriquez; Barrie J Gatus; David M Whiley; Ying-Ru Lo; Naoko Ishikawa; Teodora Wi; Monica M Lahra
Journal:  PLoS One       Date:  2019-04-03       Impact factor: 3.240

6.  In Vitro Efficacy of Gentamicin Alone and in Combination with Ceftriaxone, Ertapenem, and Azithromycin against Multidrug-Resistant Neisseria gonorrhoeae.

Authors:  Xuechun Li; Wenjing Le; Xiangdi Lou; Biwei Wang; Caroline A Genco; Peter A Rice; Xiaohong Su
Journal:  Microbiol Spectr       Date:  2021-10-20

7.  Gentamicin susceptibility of Neisseria gonorrhoeae isolates from 7 provinces in China.

Authors:  Jing-Wei Liu; Wen-Qi Xu; Xiao-Yu Zhu; Xiu-Qin Dai; Shao-Chun Chen; Yan Han; Jun Liu; Xiang-Sheng Chen; Yue-Ping Yin
Journal:  Infect Drug Resist       Date:  2019-08-09       Impact factor: 4.003
  7 in total

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