Literature DB >> 27736074

Total Synthesis of Nannocystin A.

Zhantao Yang1,2, Xiaolong Xu1, Chun-Hua Yang1,2, Yunfeng Tian1, Xinyi Chen1, Lihui Lian1, Wenwei Pan1, Xuncheng Su3, Weicheng Zhang1, Yue Chen1.   

Abstract

Nannocystin A is a 21-membered cyclodepsipeptide showing remarkable anticancer properties. Described is the total synthesis of nannocystin A, which features an asymmetric vinylogous Mukaiyama aldol reaction for efficient assembly of the penultimate open-chain precursor and a pivotal intramolecular Heck cross-coupling for the final macrocyclization.

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Year:  2016        PMID： 27736074     DOI： 10.1021/acs.orglett.6b02729

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  5 in total

Review 1.  Total syntheses of the archazolids: an emerging class of novel anticancer drugs.

Authors:  Stephan Scheeff; Dirk Menche
Journal:  Beilstein J Org Chem       Date:  2017-06-07       Impact factor: 2.883

Review 2.  Very Recent Advances in Vinylogous Mukaiyama Aldol Reactions and Their Applications to Synthesis.

Authors:  Martin Cordes; Markus Kalesse
Journal:  Molecules       Date:  2019-08-22       Impact factor: 4.411

Review 3.  An Overview of Saturated Cyclic Ethers: Biological Profiles and Synthetic Strategies.

Authors:  Qili Lu; Dipesh S Harmalkar; Yongseok Choi; Kyeong Lee
Journal:  Molecules       Date:  2019-10-21       Impact factor: 4.411

Review 4.  From Target-Oriented to Motif-Oriented: A Case Study on Nannocystin Total Synthesis.

Authors:  Weicheng Zhang
Journal:  Molecules       Date:  2020-11-15       Impact factor: 4.411

5.  Optimization of Two Steps in Scale-Up Synthesis of Nannocystin A.

Authors:  Tingrong Zhang; Shaojie Miao; Mingxiao Zhang; Wenjie Liu; Liang Wang; Yue Chen
Journal:  Mar Drugs       Date:  2021-03-31       Impact factor: 5.118
  5 in total

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