BACKGROUND: There are conflicting reports on the correlation between vitiligo and the levels of either superoxide dismutase (SOD) or malondialdehyde (MDA). AIM: To clarify the association between vitiligo and SOD or MDA. METHODS: Relevant published articles were searched according to our eligibility criteria. A meta-analysis was conducted to pool estimates of the standardized mean difference (SMD) with 95% CI. RESULTS: Patients with either the active or stable vitiligo had higher levels of both SOD (stable: SMD = 1.61, 95% CI 0.66-2.56, P = 0.001; active: SMD = 2.56, 95% CI 1.13-3.99, P < 0.001) and MDA (stable: SMD = 2.70, 95% CI 1.81-3.59, P < 0.001; active: SMD = 3.50, 95% CI 2.29-4.71, P < 0.001), compared with healthy controls. CONCLUSIONS: This meta-analysis showed a significant association between vitiligo and high levels of both SOD and MDA.
BACKGROUND: There are conflicting reports on the correlation between vitiligo and the levels of either superoxide dismutase (SOD) or malondialdehyde (MDA). AIM: To clarify the association between vitiligo and SOD or MDA. METHODS: Relevant published articles were searched according to our eligibility criteria. A meta-analysis was conducted to pool estimates of the standardized mean difference (SMD) with 95% CI. RESULTS:Patients with either the active or stable vitiligo had higher levels of both SOD (stable: SMD = 1.61, 95% CI 0.66-2.56, P = 0.001; active: SMD = 2.56, 95% CI 1.13-3.99, P < 0.001) and MDA (stable: SMD = 2.70, 95% CI 1.81-3.59, P < 0.001; active: SMD = 3.50, 95% CI 2.29-4.71, P < 0.001), compared with healthy controls. CONCLUSIONS: This meta-analysis showed a significant association between vitiligo and high levels of both SOD and MDA.
Authors: Abudujilili Abuduaini; Xueying Lu; Deng Zang; Tao Wu; Haji Akbar Aisa Journal: Evid Based Complement Alternat Med Date: 2021-04-19 Impact factor: 2.629