| Literature DB >> 27734150 |
Alexander Brobeil1,2, Eric Dietel3, Stefan Gattenlöhner4, Monika Wimmer3.
Abstract
The protein tyrosine phosphatase interacting protein 51 (PTPIP51) is thought to regulate crucial cellular functions such as mitosis, apoptosis, migration, differentiation and communication between organelles as a scaffold protein. These diverse functions are modulated by the tyrosine/serine phosphorylation status of PTPIP51. This review interconnects the insights obtained about the action of PTPIP51 in mitogen-activated protein kinase signaling, nuclear factor kB signaling, calcium homeostasis and chromosomal segregation and identifies important signaling hubs. The interference of PTPIP51 in such multiprotein complexes and their PTPIP51-modulated cross-talk makes PTPIP51 an ideal target for novel drugs such as the small molecule LDC-3. Graphical Abstract ᅟ.Entities:
Keywords: LDC-3; Mitogen activated protein kinase (MAPK) pathway; Protein complexes; Protein tyrosine phosphatase interacting protein 51 (PTPIP51); Protein-protein interaction (PPI)
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Year: 2016 PMID： 27734150 DOI： 10.1007/s00441-016-2508-5
Source DB: PubMed Journal: Cell Tissue Res ISSN： 0302-766X Impact factor: 5.249