Literature DB >> 27733708

Integrase strand transfer inhibitor-associated diabetes mellitus: A case report.

Peter S Fong1, Devon M Flynn1, Christopher D Evans1, P Todd Korthuis1.   

Abstract

Integrase strand transfer inhibitors (INSTIs) have become integral antiretroviral therapy (ART) agents for treating HIV infection. We report the case of a 44-year-old male with a history of hemophilia A who developed diabetes mellitus four months after switching from abacavir, lamivudine, and efavirenz to abacavir, lamivudine, and raltegravir. Hemoglobin A1C normalized without further need for exogenous insulin after raltegravir was switched back to efavirenz. In this case report, we will review a possible mechanism for INSTI-induced hyperglycemia and/or diabetes mellitus.

Entities:  

Keywords:  HIV; Integrase inhibitors; diabetes mellitus; raltegravir

Mesh：

Substances：

Year:  2016        PMID： 27733708     DOI： 10.1177/0956462416675107

Source DB:  PubMed          Journal:  Int J STD AIDS        ISSN： 0956-4624            Impact factor:   1.359


  15 in total

Review 1.  Factors Associated With Insulin Resistance in Adults With HIV Receiving Contemporary Antiretroviral Therapy: a Brief Update.

Authors:  Todd Hulgan
Journal:  Curr HIV/AIDS Rep       Date:  2018-06       Impact factor: 5.071

Review 2.  Beyond one pill, once daily: current challenges of antiretroviral therapy management in the United States.

Authors:  Mary Clare Masters; Karen M Krueger; Janna L Williams; Lindsay Morrison; Susan E Cohn
Journal:  Expert Rev Clin Pharmacol       Date:  2019-12       Impact factor: 5.045

Review 3.  Adipose Tissue in HIV Infection.

Authors:  John R Koethe
Journal:  Compr Physiol       Date:  2017-09-12       Impact factor: 9.090

4.  Brief Report: Weight Gain in Persons With HIV Switched From Efavirenz-Based to Integrase Strand Transfer Inhibitor-Based Regimens.

Authors:  Jamison Norwood; Megan Turner; Carmen Bofill; Peter Rebeiro; Bryan Shepherd; Sally Bebawy; Todd Hulgan; Stephen Raffanti; David W Haas; Timothy R Sterling; John R Koethe
Journal:  J Acquir Immune Defic Syndr       Date:  2017-12-15       Impact factor: 3.731

Review 5.  Metabolic Consequences of Antiretroviral Therapy.

Authors:  Caroline E Diggins; Samuel C Russo; Janet Lo
Journal:  Curr HIV/AIDS Rep       Date:  2022-03-17       Impact factor: 5.071

6.  Metabolic Changes Associated With the Use of Integrase Strand Transfer Inhibitors Among Virally Controlled Women.

Authors:  Nathan A Summers; Cecile D Lahiri; Christine D Angert; Amalia Aldredge; C Christina Mehta; Ighovwerha Ofotokun; Anne M Kerchberger; Deborah Gustafson; Sheri D Weiser; Seble Kassaye; Deborah Konkle-Parker; Anjali Sharma; Adaora A Adimora; Hector Bolivar; Jennifer Cocohoba; Audrey L French; Elizabeth T Golub; Anandi N Sheth
Journal:  J Acquir Immune Defic Syndr       Date:  2020-11-01       Impact factor: 3.771

7.  Switch to dolutegravir is well tolerated in Thais with HIV infection.

Authors:  Orlanda Q Goh; Donn J Colby; Suteeraporn Pinyakorn; Carlo Sacdalan; Eugène Kroon; Phillip Chan; Nitiya Chomchey; Ratchapong Kanaprach; Peeriya Prueksakaew; Duanghathai Suttichom; Rapee Trichavaroj; Serena Spudich; Merlin L Robb; Praphan Phanuphak; Nittaya Phanuphak; Jintanat Ananworanich
Journal:  J Int AIDS Soc       Date:  2019-07       Impact factor: 5.396

Review 8.  HIV-1 Integrase Inhibitors: A Comparative Review of Efficacy and Safety.

Authors:  Kimberly K Scarsi; Joshua P Havens; Anthony T Podany; Sean N Avedissian; Courtney V Fletcher
Journal:  Drugs       Date:  2020-11       Impact factor: 9.546

9.  Risk of Incident Diabetes Mellitus, Weight Gain, and Their Relationships With Integrase Inhibitor-Based Initial Antiretroviral Therapy Among Persons With Human Immunodeficiency Virus in the United States and Canada.

Authors:  Peter F Rebeiro; Cathy A Jenkins; Aihua Bian; Jordan E Lake; Kassem Bourgi; Richard D Moore; Michael A Horberg; W Christopher Matthews; Michael J Silverberg; Jennifer Thorne; Angel M Mayor; Viviane D Lima; Frank J Palella; Michael S Saag; Keri N Althoff; M John Gill; Cherise Wong; Marina B Klein; Heidi M Crane; Vincent C Marconi; Bryan E Shepherd; Timothy R Sterling; John R Koethe
Journal:  Clin Infect Dis       Date:  2021-10-05       Impact factor: 20.999

10.  Weight Gain in Incarcerated Individuals Living With HIV After Switching to Integrase Strand Inhibitor-Based Therapy.

Authors:  Rachel N Goldberg; Alexandra T Kania; Sarah M Michienzi; Mahesh Patel; Melissa E Badowski
Journal:  J Int Assoc Provid AIDS Care       Date:  2021 Jan-Dec
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