Literature DB >> 27732834

Overcoming ATM Deficiency by Activating the NAD+/SIRT1 Axis.

Leonard Guarente1.   

Abstract

In this issue, Fang et al. (2016) show that both the DNA repair defect and mitochondrial dysfunction in ATM-/- cells or mice are mitigated by the anti-aging compound nicotinamide riboside or a SIRT1 activator. This broad suppression by activating the NAD+/SIRT1 axis may generally apply to diseases and aging maladies.
Copyright © 2016 Elsevier Inc. All rights reserved.

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Year:  2016        PMID： 27732834     DOI： 10.1016/j.cmet.2016.09.019

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  2 in total

1.  Loss of SIRT1 in diabetes accelerates DNA damage-induced vascular calcification.

Authors:  Francesca Bartoli-Leonard; Fiona L Wilkinson; Andrew Schiro; Ferdinand Serracino Inglott; M Yvonne Alexander; Ria Weston
Journal:  Cardiovasc Res       Date:  2021-02-22       Impact factor: 10.787

2.  SIRT3, a metabolic target linked to ataxia-telangiectasia mutated (ATM) gene deficiency in diffuse large B-cell lymphoma.

Authors:  Kavita Bhalla; Sausan Jaber; Kayla Reagan; Arielle Hamburg; Karen F Underwood; Aditya Jhajharia; Maninder Singh; Binny Bhandary; Shambhu Bhat; Nahid M Nanaji; Ruching Hisa; Carrie McCracken; Heather Huot Creasy; Rena G Lapidus; Tami Kingsbury; Dirk Mayer; Brian Polster; Ronald B Gartenhaus
Journal:  Sci Rep       Date:  2020-12-03       Impact factor: 4.379
  2 in total

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