| Literature DB >> 27730346 |
Aline G Cozer1, Márcia Trapp2, Claudia Vieira Marques2, Tiago L Martins2, Jorge Felipe A Model2, Vanessa Schein2, Luiz Carlos Kucharski2, Roselis S M Da Silva2.
Abstract
The present work assesses in vitro the role of human Stanniocalcin 1 (hSTC-1) in glucose metabolism in white retroperitoneal adipose tissue (WRAT) from fed rat. In the fed state, hSTC1 increases the incorporation of 14C from glucose into lipids in the rat WRAT. The increase in lipogenesis capacity supports the hypothesis that the activity of the glycerol-3-phosphate-generating pathway (glycolysis) from glucose is regulated by hSTC-1. The effect of hSTC-1 on de novo fatty acid synthesis and on glucose oxidation in WRAT is supported by an 85 % increase in 14CO2 production from 14C-glucose. The incubation of WRAT in the presence of hSTC-1 maintained the ADP/ATP ratio close to the control group. The presence of hSTC-1 in the incubation medium did not inhibit the lipolytic effect of epinephrine. In conclusion, hSTC-1 is one of the hormonal factors that control glucose metabolism in WRAT in the fed state.Entities:
Keywords: Endocrinology; Lipid metabolism
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Year: 2016 PMID： 27730346 DOI： 10.1007/s11745-016-4202-5
Source DB: PubMed Journal: Lipids ISSN： 0024-4201 Impact factor: 1.880