Literature DB >> 27728802

Targeting HIF2α in Clear-Cell Renal Cell Carcinoma.

Christopher J Ricketts1, Daniel R Crooks1, W Marston Linehan2.   

Abstract

In two recent studies, the HIF2α antagonist, PT2399, decreased HIF2α-dependent transcription and tumor growth in selected VHL-deficient clear-cell renal cell carcinoma (ccRCC) models. These studies validate HIF2α as a therapeutic target in ccRCC, reveal variable sensitivity to HIF2α antagonism, and provide the foundation for predictive biomarker-driven clinical trials. Published by Elsevier Inc.

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Year:  2016        PMID： 27728802     DOI： 10.1016/j.ccell.2016.09.016

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  14 in total

1.  Gamma-Glutamyltransferase 1 Promotes Clear Cell Renal Cell Carcinoma Initiation and Progression.

Authors:  Ankita Bansal; Danielle J Sanchez; Vivek Nimgaonkar; David Sanchez; Romain Riscal; Nicolas Skuli; M Celeste Simon
Journal:  Mol Cancer Res       Date:  2019-05-31       Impact factor: 5.852

Review 2.  Hypoxia, angiogenesis, and metabolism in the hereditary kidney cancers.

Authors:  John C Chappell; Laura Beth Payne; W Kimryn Rathmell
Journal:  J Clin Invest       Date:  2019-01-07       Impact factor: 14.808

3.  Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity.

Authors:  Joshua D Ochocki; Sanika Khare; Markus Hess; Daniel Ackerman; Bo Qiu; Jennie I Daisak; Andrew J Worth; Nan Lin; Pearl Lee; Hong Xie; Bo Li; Bradley Wubbenhorst; Tobi G Maguire; Katherine L Nathanson; James C Alwine; Ian A Blair; Itzhak Nissim; Brian Keith; M Celeste Simon
Journal:  Cell Metab       Date:  2018-05-10       Impact factor: 27.287

4.  S100A10 Is a Critical Mediator of GAS6/AXL-Induced Angiogenesis in Renal Cell Carcinoma.

Authors:  Yiren Xiao; Hongjuan Zhao; Lei Tian; Rosalie Nolley; Anh N Diep; Anne Ernst; Katherine C Fuh; Yu Rebecca Miao; Rie von Eyben; John T Leppert; James D Brooks; Donna M Peehl; Amato J Giaccia; Erinn B Rankin
Journal:  Cancer Res       Date:  2019-10-04       Impact factor: 12.701

5.  Macrophage HIF-1α Is an Independent Prognostic Indicator in Kidney Cancer.

Authors:  Sophie J Cowman; Daniel G Fuja; Xian-De Liu; Rebecca S Slack Tidwell; Neelima Kandula; Deepika Sirohi; Archana M Agarwal; Lyska L Emerson; Sheryl R Tripp; Jeffrey S Mohlman; Miekan Stonhill; Guillermina Garcia; Christopher J Conley; Adam A Olalde; Timothy Sargis; Adela Ramirez-Torres; Jose A Karam; Christopher G Wood; Kanishka Sircar; Pheroze Tamboli; Kenneth Boucher; Benjamin Maughan; Benjamin T Spike; Thai H Ho; Neeraj Agarwal; Eric Jonasch; Mei Yee Koh
Journal:  Clin Cancer Res       Date:  2020-06-25       Impact factor: 12.531

Review 6.  Metabolomics in cancer research and emerging applications in clinical oncology.

Authors:  Daniel R Schmidt; Rutulkumar Patel; David G Kirsch; Caroline A Lewis; Matthew G Vander Heiden; Jason W Locasale
Journal:  CA Cancer J Clin       Date:  2021-05-13       Impact factor: 286.130

Review 7.  Hereditary kidney cancer syndromes: Genetic disorders driven by alterations in metabolism and epigenome regulation.

Authors:  Hisashi Hasumi; Masahiro Yao
Journal:  Cancer Sci       Date:  2018-02-15       Impact factor: 6.716

8.  Comprehensive characterization of immune- and inflammation-associated biomarkers based on multi-omics integration in kidney renal clear cell carcinoma.

Authors:  Enyang Zhao; Lihong Li; Wenfu Zhang; Wanhui Wang; Yunhui Chan; Bosen You; Xuedong Li
Journal:  J Transl Med       Date:  2019-05-27       Impact factor: 5.531

9.  Functional significance of germline EPAS1 variants.

Authors:  Trisha Dwight; Edward Kim; Karine Bastard; Diana E Benn; Graeme Eisenhofer; Susan Richter; Massimo Mannelli; Elena Rapizzi; Aleksander Prejbisz; Mariola Pęczkowska; Karel Pacak; Roderick Clifton-Bligh
Journal:  Endocr Relat Cancer       Date:  2021-02       Impact factor: 5.678

10.  Prognostic significance and immune correlates of CD73 expression in renal cell carcinoma.

Authors:  Abhishek Tripathi; Edwin Lin; Wanling Xie; Abdallah Flaifel; John A Steinharter; Emily N Stern Gatof; Gabrielle Bouchard; Justin H Fleischer; Nieves Martinez-Chanza; Connor Gray; Charlene Mantia; Linda Thompson; Xiao X Wei; Marios Giannakis; Bradley A McGregor; Toni K Choueiri; Neeraj Agarwal; David F McDermott; Sabina Signoretti; Lauren C Harshman
Journal:  J Immunother Cancer       Date:  2020-11       Impact factor: 13.751
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