Literature DB >> 27728797

SOX2 Determines Lineage Restriction: Modeling Lung Squamous Cell Carcinoma in the Mouse.

Nicole R Murray1, Verline Justilien1, Alan P Fields2.   

Abstract

In this issue of Cancer Cell, Ferone et al. demonstrate that SOX2 not only drives lung tumor formation but also restricts tumor lineage to squamous cell carcinoma (LSCC), regardless of cell of origin. This novel LSCC model should facilitate identification of key oncogenic drivers and treatment strategies for this lung cancer subtype.
Copyright © 2016 Elsevier Inc. All rights reserved.

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Year:  2016        PMID： 27728797     DOI： 10.1016/j.ccell.2016.09.012

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  7 in total

1.  Sox2 modulates motility and enhances progression of colorectal cancer via the Rho-ROCK signaling pathway.

Authors:  Junheng Zheng; Lixiao Xu; Yubin Pan; Shuyi Yu; Hongbo Wang; Derek Kennedy; Yan Zhang
Journal:  Oncotarget       Date:  2017-10-10

2.  MiR-638 acts as a tumor suppressor gene in gastric cancer.

Authors:  Yu Shen; Haiqun Chen; Ling Gao; Weigang Zhang; Jun He; Xiaohua Yang; Lei Qin; Xiaofeng Xue; Zhaoji Guo
Journal:  Oncotarget       Date:  2017-11-20

3.  Knockdown of long non-coding RNA NEAT1 inhibits glioma cell migration and invasion via modulation of SOX2 targeted by miR-132.

Authors:  Ke Zhou; Chi Zhang; Hui Yao; Xuewen Zhang; Youxin Zhou; Yanjun Che; Yulun Huang
Journal:  Mol Cancer       Date:  2018-07-27       Impact factor: 27.401

Review 4.  Functional characterization of SOX2 as an anticancer target.

Authors:  Shizhen Zhang; Xiufang Xiong; Yi Sun
Journal:  Signal Transduct Target Ther       Date:  2020-07-29

5.  Prognostic Value of CD133 and SOX2 in Advanced Cancer.

Authors:  Susu Han; Tao Huang; Xing Wu; Xiyu Wang; Shanshan Liu; Wei Yang; Qi Shi; Hongjia Li; Fenggang Hou
Journal:  J Oncol       Date:  2019-01-01       Impact factor: 4.375

Review 6.  Applications of patient-derived tumor xenograft models and tumor organoids.

Authors:  Go J Yoshida
Journal:  J Hematol Oncol       Date:  2020-01-07       Impact factor: 17.388

7.  Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation.

Authors:  Charles M Rudin; Alvaro Quintanal-Villalonga; Hirokazu Taniguchi; Yingqian A Zhan; Maysun M Hasan; Shweta S Chavan; Fanli Meng; Fathema Uddin; Viola Allaj; Parvathy Manoj; Nisargbhai S Shah; Joseph M Chan; Metamia Ciampricotti; Andrew Chow; Michael Offin; Jordana Ray-Kirton; Jacklynn D Egger; Umesh K Bhanot; Irina Linkov; Marina Asher; Michael H Roehrl; Katia Ventura; Juan Qiu; Elisa de Stanchina; Jason C Chang; Natasha Rekhtman; Brian Houck-Loomis; Richard P Koche; Helena A Yu; Triparna Sen
Journal:  J Hematol Oncol       Date:  2021-10-16       Impact factor: 17.388
  7 in total

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