| Literature DB >> 27726391 |
Jong Won Kim1, Sung-Kyun Ko1,2, Hye-Min Kim1,2, Gun-Hee Kim1, Sangkeun Son1,2, Gil Soo Kim1,2, Gwi Ja Hwang1,2, Eun Soo Jeon1, Kee-Sun Shin3, In-Ja Ryoo1, Young-Soo Hong1,2, Hyuncheol Oh4, Kyung Ho Lee1, Nak-Kyun Soung1,2, Daisuke Hashizume5, Toshihiko Nogawa6, Shunji Takahashi6,7, Bo Yeon Kim1,2, Hiroyuki Osada6, Jae-Hyuk Jang1,2, Jong Seog Ahn1,2.
Abstract
Two new phenylspirodrimane derivatives, stachybotrysin (1) and stachybotrylactone B (2), were isolated from the cultures of the marine-derived fungus Stachybotrys sp. KCB13F013. The structures were determined by analyzing the spectroscopic data (1D and 2D NMR and MS) and chemical transformation, including the modified Mosher's method and single-crystal X-ray structure analysis. Compound 1 exhibited an inhibitory effect on osteoclast differentiation in bone marrow macrophage cells via suppressing the RANKL-induced activation of p-ERK, p-JNK, p-p38, c-Fos, and NFATc1.Entities:
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Year: 2016 PMID： 27726391 DOI： 10.1021/acs.jnatprod.6b00641
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050