Literature DB >> 27725900

Identification of HRAS as cancer-promoting gene in gastric carcinoma cell aggressiveness.

Xiao Yu Wu1, Wen Tao Liu2, Zhen Feng Wu1, Che Chen1, Jia Yun Liu1, Guan Nan Wu1, Xue Quan Yao1, Fu Kun Liu1, Gang Li3.   

Abstract

Gastric carcinoma is one of the most lethal malignancies of cancers and its prognosis remains dismal due to the paucity of effective therapeutic targets. Herein, we showed that HRAS is markedly up-regulated in gastric carcinoma. Prognostic analysis indicated that HRAS expression might be a prognostic indicator for the survival of patients with gastric carcinoma. Ectopic expression of HRAS in gastric carcinoma cells accelerated proliferation, migration, invasion, angiogenesis, and clone formation ability of gastric carcinoma cells in vitro. Furthermore, HRAS over-expressing significantly promoted the tumorigenicity of gastric carcinoma cells in vivo whereas silencing endogenous HRAS caused opposite outcomes. Moreover, we demonstrated that HRAS enhanced gastric carcinoma aggressiveness by activating VEGFA/PI3K/AKT pathway and Raf-1 signaling. Together, our results provide new evidence that HRAS overexpression promotes the progression of gastric carcinoma and might represent a novel therapeutic target for its treatment.

Entities:  

Keywords:  HRAS; angiogenesis; gastric carcinoma; growth

Year:  2016        PMID： 27725900      PMCID： PMC5043104     

Source DB:  PubMed          Journal:  Am J Cancer Res        ISSN： 2156-6976            Impact factor:   6.166


  28 in total

1.  A novel all-trans retinoic acid derivative inhibits proliferation and induces differentiation of human gastric carcinoma xenografts via up-regulating retinoic acid receptor β.

Authors:  Jing Ju; Nan Wang; Xinqun Wang; Feihu Chen
Journal:  Am J Transl Res       Date:  2015-05-15       Impact factor: 4.060

2.  FBXO31 promotes cell proliferation, metastasis and invasion in lung cancer.

Authors:  Hai-Li Huang; Yun Jiang; Ya-Hong Wang; Ting Chen; Hui-Juan He; Tie Liu; Teng Yang; La-Wei Yang; Jie Chen; Ze-Qing Song; Weimin Yao; Bin Wu; Gang Liu
Journal:  Am J Cancer Res       Date:  2015-04-15       Impact factor: 6.166

3.  Downregulation of human intercellular adhesion molecule-1 attenuates the metastatic ability in human breast cancer cell lines.

Authors:  Dalin Di; Lei Chen; Lina Wang; Ping Sun; Yanfei Liu; Zhiwei Xu; Jiyu Ju
Journal:  Oncol Rep       Date:  2016-01-05       Impact factor: 3.906

4.  Methylation-associated silencing of MicroRNA-335 contributes tumor cell invasion and migration by interacting with RASA1 in gastric cancer.

Authors:  Zhengrong Li; Daojiang Li; Guoyang Zhang; Jianbo Xiong; Zhigang Jie; Heping Cheng; Yi Cao; Mengmeng Jiang; Liangqing Lin; Zhibiao Le; Shengxing Tan; Wenyu Zou; Binbin Gong; Shengrong Lin; Ke Yang
Journal:  Am J Cancer Res       Date:  2014-11-19       Impact factor: 6.166

5.  In vivo pharmacokinetics, biodistribution and antitumor effect of amphiphilic poly(L-amino acids) micelles loaded with a novel all-trans retinoic acid derivative.

Authors:  Jihui Tang; Xinqun Wang; Ting Wang; Feihu Chen; Jianping Zhou
Journal:  Eur J Pharm Sci       Date:  2013-09-26       Impact factor: 4.384

Review 6.  Role of RAS in the regulation of PI 3-kinase.

Authors:  Esther Castellano; Julian Downward
Journal:  Curr Top Microbiol Immunol       Date:  2010       Impact factor: 4.291

7.  Upregulated INHBA expression is associated with poor survival in gastric cancer.

Authors:  Quan Wang; Yu-Gang Wen; Da-Peng Li; Jun Xia; Chong-Zhi Zhou; Dong-Wang Yan; Hua-Mei Tang; Zhi-Hai Peng
Journal:  Med Oncol       Date:  2010-12-04       Impact factor: 3.064

8.  Frequency of KRAS, BRAF, and NRAS mutations in colorectal cancer.

Authors:  Cecily P Vaughn; Scott D Zobell; Larissa V Furtado; Christine L Baker; Wade S Samowitz
Journal:  Genes Chromosomes Cancer       Date:  2011-02-08       Impact factor: 5.006

9.  Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), enhances anti-tumor effects of the poly (ADP-ribose) polymerase (PARP) inhibitor olaparib in triple-negative breast cancer cells.

Authors:  Ahrum Min; Seock-Ah Im; Debora Keunyoung Kim; Sang-Hyun Song; Hee-Jun Kim; Kyung-Hun Lee; Tae-Yong Kim; Sae-Won Han; Do-Youn Oh; Tae-You Kim; Mark J O'Connor; Yung-Jue Bang
Journal:  Breast Cancer Res       Date:  2015-03-07       Impact factor: 6.466

10.  HOXB9 induction of mesenchymal-to-epithelial transition in gastric carcinoma is negatively regulated by its hexapeptide motif.

Authors:  Qing Chang; Li Zhang; Changyu He; Baogui Zhang; Jun Zhang; Bingya Liu; Naiyan Zeng; Zhenggang Zhu
Journal:  Oncotarget       Date:  2015-12-15
View more
  13 in total

1.  MIR-519d suppresses the gastric cancer epithelial-mesenchymal transition via Twist1 and inhibits Wnt/β-catenin signaling pathway.

Authors:  Hailing Yue; Bo Tang; Yongliang Zhao; Yanyang Niu; Peng Yin; Weijun Yang; Zhigang Zhang; Peiwu Yu
Journal:  Am J Transl Res       Date:  2017-08-15       Impact factor: 4.060

2.  Identification and Validation of SNP-Containing Genes With Prognostic Value in Gastric Cancer via Integrated Bioinformatics Analysis.

Authors:  Hui Li; Jing Guo; Guang Cheng; Yucheng Wei; Shihai Liu; Yaoyue Qi; Gongjun Wang; Ruoxi Xiao; Weiwei Qi; Wensheng Qiu
Journal:  Front Oncol       Date:  2021-04-27       Impact factor: 6.244

3.  Parthenolide suppresses non-small cell lung cancer GLC-82 cells growth via B-Raf/MAPK/Erk pathway.

Authors:  Minting Lin; Hong Bi; Yanyan Yan; Wenjing Huang; Guiping Zhang; Genshui Zhang; Sili Tang; Yun Liu; Lingling Zhang; Jinxiang Ma; Jianye Zhang
Journal:  Oncotarget       Date:  2017-04-04

4.  Does Harvey-Ras gene expression lead to oral squamous cell carcinoma? A clinicopathological aspect.

Authors:  Akhilesh Krishna; Shraddha Singh; Vineeta Singh; Vijay Kumar; Uma Shankar Singh; Satya Narayan Sankhwar
Journal:  J Oral Maxillofac Pathol       Date:  2018 Jan-Apr

5.  Molecular profiling and comprehensive genome-wide analysis of somatic copy number alterations in gastric intramucosal neoplasias based on microsatellite status.

Authors:  Tamotsu Sugai; Makoto Eizuka; Noriyuki Arakawa; Mitsumasa Osakabe; Wataru Habano; Yasuko Fujita; Eiichiro Yamamoto; Hiroo Yamano; Masaki Endoh; Takayuki Matsumoto; Hiromu Suzuki
Journal:  Gastric Cancer       Date:  2018-02-21       Impact factor: 7.370

6.  Clinical significance of HRAS and KRAS genes expression in patients with non-small-cell lung cancer - preliminary findings.

Authors:  Milena Pązik; Katarzyna Michalska; Marta Żebrowska-Nawrocka; Izabela Zawadzka; Mariusz Łochowski; Ewa Balcerczak
Journal:  BMC Cancer       Date:  2021-02-06       Impact factor: 4.430

7.  Strain-specific behavior of Mycobacterium tuberculosis in A549 lung cancer cell line.

Authors:  Shima Hadifar; Shayan Mostafaei; Ava Behrouzi; Abolfazl Fateh; Parisa Riahi; Seyed Davar Siadat; Farzam Vaziri
Journal:  BMC Bioinformatics       Date:  2021-03-25       Impact factor: 3.169

8.  Gene master regulators of papillary and anaplastic thyroid cancers.

Authors:  Dumitru A Iacobas; Neha Y Tuli; Sanda Iacobas; John K Rasamny; Augustine Moscatello; Jan Geliebter; Raj K Tiwari
Journal:  Oncotarget       Date:  2017-12-19

9.  Whole-genome sequencing of esophageal adenocarcinoma in Chinese patients reveals distinct mutational signatures and genomic alterations.

Authors:  James Y Dai; Xiaoyu Wang; Matthew F Buas; Chengjuan Zhang; Jie Ma; Bing Wei; Yin Li; Baosheng Zhao; Teresa S Hyun; Xueyan Chen; Keith R Loeb; Robert Odze; Lena Yao; Xin Sun; Steve Self; Thomas L Vaughan; Yongjun Guo
Journal:  Commun Biol       Date:  2018-10-24

10.  Experimental, Clinical and Morphological Analysis of H-Ras Oncoproteins for Locally Advanced Breast Cancer.

Authors:  A M Zhumakayeva; K D Rakhimov; I M Omarova; L I Arystan; S M Adekenov
Journal:  Open Access Maced J Med Sci       Date:  2019-10-10
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.