Literature DB >> 277259

Nitropyrrole radiosensitizers: structure function relationships.

J A Raleigh, J D Chapman, A P Reuvers, J E Biaglow, R E Durand, A M Rauth.   

Abstract

Nitropyrrole derivatives have been tested as hypoxic cell radiosensitizers in vitro and in vivo. Radiosensitizing potential generally increases with nitropyrrole electron affinity. N-hydroxyethyl substitution decreases toxicity relative to N--CH3, N--CH2 CH3 and N--CH2 CH2 CH3 substitution. The most effective nitropyrrole tested in vivo is N-hydroxyethyl-2-cyano-5-nitropyrrole (NP-1).

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Year:  1978        PMID： 277259      PMCID： PMC2149400     

Source DB:  PubMed          Journal:  Br J Cancer Suppl        ISSN： 0306-9443


  15 in total

1.  HYDRATED ELECTRONS AND RADIOBIOLOGICAL SENSITISATION.

Authors:  G E ADAMS; D L DEWEY
Journal:  Biochem Biophys Res Commun       Date:  1963-08-20       Impact factor: 3.575

2.  Radiosensitizers of hypoxic cells in solid tumors.

Authors:  J F Fowler; G E Adams; J Denekamp
Journal:  Cancer Treat Rev       Date:  1976-12       Impact factor: 12.111

3.  Effects of sensitizers on cell respiration: 1. Factors influencing the effects of hypoxic cell radiosensitizers on oxygen utilization of tumour and cultured mammalian cells.

Authors:  J E Biaglow; C L Greenstock; R E Durand
Journal:  Br J Cancer Suppl       Date:  1978-06

4.  Letter: Modification of the radiation response of an in vitro tumour model by control of cellular respiration.

Authors:  R E Durand; J E Biaglow
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1974-12

5.  Hypoxic cells in an in vitro tumour model.

Authors:  R M Sutherland; R E Durand
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1973-03

6.  Nitrofurans as radiosensitizers of hypoxic mammalian cells.

Authors:  J D Chapman; A P Reuvers; J Borsa; A Petkau; D R McCalla
Journal:  Cancer Res       Date:  1972-12       Impact factor: 12.701

7.  [Activity on Trichomonas vaginalis and other chemotherapeutic properties of 1-(2-hydroxyethyl)-2-carbamoyl-5-nitropyrrole (15,960 RP)].

Authors:  F Bénazet; C Cosar; P Ganter; L Julou; P Populaire; L Guillaume
Journal:  C R Acad Hebd Seances Acad Sci D       Date:  1966-08-08

8.  Radiosensitization of mammalian cells by p-nitroacetophenone. I. Characterization in asynchronous and synchronous populations.

Authors:  J D Chapman; R G Webb; J Borsa
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1971

9.  Effect of nitrobenzene derivatives on electron transfer in cellular and chemical models.

Authors:  J E Biaglow; B Jacobson
Journal:  Mol Pharmacol       Date:  1977-03       Impact factor: 4.436

10.  Effects of dimethyl sulfoxide and hypoxic cell radiosensitizers on the radiation response of the KHT murine tumor in vivo.

Authors:  A M Rauth; J E Paciga
Journal:  Radiat Res       Date:  1977-02       Impact factor: 2.841
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