Literature DB >> 277255

Radiation damage to DNA in aqueous solution: effects of radiosensitizers.

J F Ward.   

Abstract

Systems are described for examining the molecular mode of action of anoxic radiosensitisers with DNA-OH radicals. Pulse radiolysis showed that NPPN reacts with these radicals even in the presence of 0.5 mM oxygen. Analysis of low molecular weight products liberated from DNA by irradiation showed that NPPN does not act in an oxygen-like way but that misonidazole does. Thus a molecular rationale exists for the use of combinations of radiosensitizers.

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Year:  1978        PMID： 277255      PMCID： PMC2149368     

Source DB:  PubMed          Journal:  Br J Cancer Suppl        ISSN： 0306-9443


  3 in total

1.  Strand breaks, base release, and postirradiation changes in DNA gamma-irradiated in dilute O2-saturated aqueous solution.

Authors:  J F Ward; I Kuo
Journal:  Radiat Res       Date:  1976-06       Impact factor: 2.841

2.  Polyfunctional radiosensitizers III. Effect of the biradical (Ro-03-303) in combination with other radiosensitizers on the survival of hypoxic V-79 cells.

Authors:  B C Millar; E M Fielden; C E Smithen
Journal:  Radiat Res       Date:  1977-03       Impact factor: 2.841

3.  Pulse radiolysis studies of the radiosensitizer Nor-pseudopelletierine-N-oxyl (NPPN). II. Reactions involving biological radicals.

Authors:  P B Roberts; E M Fielden
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1971
  3 in total

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