Naohisa Tomosugi1, Shoko Yamamoto2, Masayoshi Takeuchi3, Hideto Yonekura4, Yasuhito Ishigaki5, Noriaki Numata2, Shogo Katsuda6, Yasuo Sakai2. 1. Division of Aging Research, Department of Advanced Medicine, Medical Research Institute, Kanazawa Medical University. 2. Central Research Institute, Jellice Co., Ltd. 3. Division of AGEs Research, Department of Advanced Medicine, Medical Research Institute, Kanazawa Medical University. 4. Department of Biochemistry II, Kanazawa Medical University. 5. Division of Molecular Oncology and Virology, Department of Life Science, Medical Research Institute, Kanazawa Medical University. 6. Department of Pathology II, President of Kanazawa Medical University.
Abstract
AIM: Collagen tripeptide (CTP) is a functional food with a high content of Gly-X-Y tripeptides derived from collagen. The objective of this study was to evaluate the effect of CTP administration on the development of atherosclerosis in healthy individuals. METHODS: The present study was conducted in the form of an open-label, single-dose trial for 6 months. All subjects ingested CTP twice daily: at breakfast and supper (total intake per day: 16 g). The effect of CTP on atherosclerosis was verified by measuring several indices, including serum lipid levels, toxic advanced glycation end-products (TAGE), and the cardio-ankle vascular index (CAVI), at baseline and 6 months. RESULTS: The low-density lipoprotein cholesterol (LDL-C) to high-density lipoprotein cholesterol (HDL-C) ratio (LDL-C/HDL-C ratio) was significantly reduced in patients with an initial ratio of ≥2.5 (p=0.025). A significant reduction in TAGE was observed in all the subjects (p=0.031) and in the high-risk group (p=0.024). A significant reduction in CAVI was observed in all the subjects (right side: p=0.048, left side: p=0.047). As a result of multiple regression analysis, a significant relationship between the change in CAVI and that in each factor was not observed. No adverse events were observed during the study period. CONCLUSIONS: The results of the present study indicate that CTP contributes to the prevention and treatment of atherosclerosis in healthy humans (UMIN000018525).
AIM: Collagen tripeptide (CTP) is a functional food with a high content of Gly-X-Ytripeptides derived from collagen. The objective of this study was to evaluate the effect of CTP administration on the development of atherosclerosis in healthy individuals. METHODS: The present study was conducted in the form of an open-label, single-dose trial for 6 months. All subjects ingested CTP twice daily: at breakfast and supper (total intake per day: 16 g). The effect of CTP on atherosclerosis was verified by measuring several indices, including serum lipid levels, toxic advanced glycation end-products (TAGE), and the cardio-ankle vascular index (CAVI), at baseline and 6 months. RESULTS: The low-density lipoprotein cholesterol (LDL-C) to high-density lipoprotein cholesterol (HDL-C) ratio (LDL-C/HDL-C ratio) was significantly reduced in patients with an initial ratio of ≥2.5 (p=0.025). A significant reduction in TAGE was observed in all the subjects (p=0.031) and in the high-risk group (p=0.024). A significant reduction in CAVI was observed in all the subjects (right side: p=0.048, left side: p=0.047). As a result of multiple regression analysis, a significant relationship between the change in CAVI and that in each factor was not observed. No adverse events were observed during the study period. CONCLUSIONS: The results of the present study indicate that CTP contributes to the prevention and treatment of atherosclerosis in healthy humans (UMIN000018525).
Entities:
Keywords:
Atherosclerosis; CAVI; CTP; LDL-C/HDL-C ratio; TAGE
Authors: Petr Dobsak; Vladimir Soska; Ondrej Sochor; Jiri Jarkovsky; Marie Novakova; Martin Homolka; Miroslav Soucek; Petra Palanova; Francisco Lopez-Jimenez; Kohji Shirai Journal: J Atheroscler Thromb Date: 2014-10-22 Impact factor: 4.928