| Literature DB >> 27725114 |
Tetsuya Akaishi1, Ichiro Nakashima2, Takayuki Takeshita3, Kimihiko Kaneko4, Shunji Mugikura5, Douglas Kazutoshi Sato6, Toshiyuki Takahashi7, Toru Nakazawa8, Masashi Aoki9, Kazuo Fujihara10.
Abstract
We compared the clinical features of optic neuritis (ON) that are frequently observed in various central nervous system demyelinating diseases, including multiple sclerosis (MS), anti-aquaporin 4 (AQP4) antibody- and anti-myelin oligodendrocyte glycoprotein (MOG) autoantibody-related diseases. Almost all the AQP4-ON patients were female, whereas half of the MOG-ON patients were male. The ON-onset age was younger in MS-ON and was older in AQP4-ON. The ON-lesion detected using optic MRI in the acute phase was longer in MOG-ON and showed severe swelling and twisting. The worst visual acuity was similar between the diseases; however, the final visual acuity was significantly worse in AQP4-ON.Entities:
Keywords: Anti-MOG autoantibody; Multiple sclerosis; Neuromyelitis optica spectrum disorder; Optic MRI; Optic neuritis; Visual prognosis
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Year: 2016 PMID： 27725114 DOI： 10.1016/j.jneuroim.2016.09.007
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478