Literature DB >> 27725113

The increased antibody response to Epstein-Barr virus in multiple sclerosis is restricted to selected virus proteins.

Matthew M Dooley1, Samantha L de Gannes1, Kristi A Fu1, J William Lindsey2.   

Abstract

Multiple sclerosis (MS) is associated with Epstein-Barr virus (EBV) infection, and the antibody response to EBV is reported to be increased in MS. EBV contains multiple antigens, and only a few have been investigated. Our hypothesis is that MS patients will have an increased antibody response to only selected EBV antigens. We used immunoprecipitation and quantitative mass spectrometry to identify candidate EBV antigens. We then measured the antibody response to 10 individual EBV proteins with quantitative ELISA. We found that the antibody response was increased in MS to three of the EBV proteins, but not to the other seven.
Copyright © 2016 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Antibody response; BFRF3; BRRF2; EBNA-1; Epstein-Barr virus; Multiple sclerosis

Mesh：

Substances：

Year:  2016        PMID： 27725113     DOI： 10.1016/j.jneuroim.2016.08.016

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  5 in total

1.  Epstein Barr virus nuclear antigen 1 (EBNA-1) peptides recognized by adult multiple sclerosis patient sera induce neurologic symptoms in a murine model.

Authors:  Neelakshi R Jog; Micah T McClain; Latisha D Heinlen; Timothy Gross; Rheal Towner; Joel M Guthridge; Robert C Axtell; Gabriel Pardo; John B Harley; Judith A James
Journal:  J Autoimmun       Date:  2019-09-09       Impact factor: 14.511

Review 2.  Viruses and endogenous retroviruses in multiple sclerosis: From correlation to causation.

Authors:  A-F A Mentis; E Dardiotis; N Grigoriadis; E Petinaki; G M Hadjigeorgiou
Journal:  Acta Neurol Scand       Date:  2017-05-23       Impact factor: 3.209

Review 3.  Epstein-Barr Virus and Multiple Sclerosis.

Authors:  Gunnar Houen; Nicole Hartwig Trier; Jette Lautrup Frederiksen
Journal:  Front Immunol       Date:  2020-12-17       Impact factor: 7.561

4.  Cumulative Roles for Epstein-Barr Virus, Human Endogenous Retroviruses, and Human Herpes Virus-6 in Driving an Inflammatory Cascade Underlying MS Pathogenesis.

Authors:  Ute-Christiane Meier; Richard Christopher Cipian; Abbas Karimi; Ranjan Ramasamy; Jaap Michiel Middeldorp
Journal:  Front Immunol       Date:  2021-11-01       Impact factor: 7.561

5.  Epstein-Barr virus is present in the brain of most cases of multiple sclerosis and may engage more than just B cells.

Authors:  Asma Hassani; John R Corboy; Suhail Al-Salam; Gulfaraz Khan
Journal:  PLoS One       Date:  2018-02-02       Impact factor: 3.240
  5 in total

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