Jie Fan1, Mingtian Zhong2, Jun Gan3, Wanting Liu3, Chaoyang Niu3, Haiyan Liao3, Hongchun Zhang3, Changlian Tan3, Jinyao Yi4, Xiongzhao Zhu5. 1. Medical Psychological center, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China; Medical Psychological institute of Central South University, Changsha, Hunan 410011, PR China. 2. Center for Studies of Psychological Application, South China Normal University, Guangzhou 510631, PR China. 3. Medical Psychological center, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China. 4. Medical Psychological center, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China. Electronic address: jinyaoyi@gmail.com. 5. Medical Psychological center, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China; Medical Psychological institute of Central South University, Changsha, Hunan 410011, PR China. Electronic address: xiongzhaozhu@163.com.
Abstract
BACKGROUND: Insight into illness is an important issue for psychiatry disorder. Although the existence of a poor insight subtype of obsessive-compulsive disorder (OCD) was recognized in the DSM-IV, and the insight level in OCD was specified further in DSM-V, the neural underpinnings of insight in OCD have been rarely explored. The present study was designed to bridge this research gap by using resting-state functional magnetic resonance imaging (fMRI). METHODS: Spontaneous neural activity were examined in 19 OCD patients with good insight (OCD-GI), 18 OCD patients with poor insight (OCD-PI), and 25 healthy controls (HC) by analyzing the amplitude of low-frequency fluctuation (ALFF) in the resting state. Pearson correlation analysis was performed between regional ALFFs and insight levels among OCD patients. RESULTS: OCD-GI and OCD-PI demonstrated overlapping and distinct brain alterations. Notably, compared with OCD-GI, tOCD-PI had reduced ALFF in left middle temporal gyrus (MTG) and right superior temporal gyrus (STG), as well as increased ALFF in right middle occipital gyrus. Further analysis revealed that ALFF values for the left MTG and right STG were correlated negatively with insight level in patients with OCD. LIMITATIONS: Relatively small sample size and not all patients were un-medicated are our major limitations. CONCLUSIONS: Spontaneous brain activity in left MTG and right STG may be neural underpinnings of insight in OCD. Our results suggest the great role of human temporal brain regions in understanding insight, and further underscore the importance of considering insight presentation in understanding the clinical heterogeneity of OCD.
BACKGROUND: Insight into illness is an important issue for psychiatry disorder. Although the existence of a poor insight subtype of obsessive-compulsive disorder (OCD) was recognized in the DSM-IV, and the insight level in OCD was specified further in DSM-V, the neural underpinnings of insight in OCD have been rarely explored. The present study was designed to bridge this research gap by using resting-state functional magnetic resonance imaging (fMRI). METHODS: Spontaneous neural activity were examined in 19 OCDpatients with good insight (OCD-GI), 18 OCDpatients with poor insight (OCD-PI), and 25 healthy controls (HC) by analyzing the amplitude of low-frequency fluctuation (ALFF) in the resting state. Pearson correlation analysis was performed between regional ALFFs and insight levels among OCDpatients. RESULTS:OCD-GI and OCD-PI demonstrated overlapping and distinct brain alterations. Notably, compared with OCD-GI, tOCD-PI had reduced ALFF in left middle temporal gyrus (MTG) and right superior temporal gyrus (STG), as well as increased ALFF in right middle occipital gyrus. Further analysis revealed that ALFF values for the left MTG and right STG were correlated negatively with insight level in patients with OCD. LIMITATIONS: Relatively small sample size and not all patients were un-medicated are our major limitations. CONCLUSIONS: Spontaneous brain activity in left MTG and right STG may be neural underpinnings of insight in OCD. Our results suggest the great role of human temporal brain regions in understanding insight, and further underscore the importance of considering insight presentation in understanding the clinical heterogeneity of OCD.
Authors: H Blair Simpson; Rachel Marsh; Tracey C Shi; David Pagliaccio; Marilyn Cyr Journal: Neuropsychopharmacology Date: 2021-01-14 Impact factor: 7.853
Authors: Diana Tordesillas-Gutierrez; Rosa Ayesa-Arriola; Manuel Delgado-Alvarado; Jennifer L Robinson; Javier Lopez-Morinigo; Jesus Pujol; M Encarnación Dominguez-Ballesteros; Anthony S David; Benedicto Crespo-Facorro Journal: PLoS One Date: 2018-06-01 Impact factor: 3.240