Literature DB >> 27723133

AuNP-Collagen Matrix with Localized Stiffness for Cardiac-Tissue Engineering: Enhancing the Assembly of Intercalated Discs by β1-Integrin-Mediated Signaling.

Yi Li1, Xiaoli Shi2,3, Lei Tian1, Hongyu Sun4, Yujing Wu1, Xia Li5, Jianjun Li2,3, Yujie Wei1, Xinxiao Han2,3, Jiao Zhang1, Xiaowei Jia1, Rui Bai1, Limin Jing1, Peng Ding1, Huiliang Liu1, Dong Han2,3.   

Abstract

A schematic for the mechanism of accelerating the assembly of intercalated discs (IDs) in cardiac myocytes regulated by gold nanoparticles (AuNPs) is presented. AuNPs with local nanoscale stiffness in the substrate activate β1-integrin signaling, which mediates the activation of integrin-linked kinase (ILK) and its downstream signal kinase by stimulating expression of the transcription factors GATA4 and MEF-2c.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  cardiac-tissue engineering; gold nanoparticles; intercalated discs; localized stiffness; β1-integrin

Mesh：

Substances：

Year:  2016        PMID： 27723133     DOI： 10.1002/adma.201603027

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  15 in total

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Review 7.  Naturally Engineered Maturation of Cardiomyocytes.

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Authors:  Min Bao; Jing Xie; Wilhelm T S Huck
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Review 9.  Cardiac tissue engineering: state-of-the-art methods and outlook.

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10.  Mussel-inspired conductive Ti2C-cryogel promotes functional maturation of cardiomyocytes and enhances repair of myocardial infarction.

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