Literature DB >> 277231

Effect of combined metronidazole and DMSO on tumour control and skin tolerance in the rat.

J E Moulder, P S Lo, J J Fischer.   

Abstract

A combination of the radiosensitizer, metronidazole, and the radioprotector, dimethyl sulfoxide (DMSO), was tested for its effects on the radiation tolerance of rat skin and on the radiosensitivity of the BA1112 rhabdomyosarcoma. The simplest interpretation of the effects of the combined treatment is that: metronidazole radiosensitizes BA1112 in one-fraction but not in five-fraction treatments; metronidazole slightly increases the radiosensitivity of skin in one-fraction treatments; metronidazole radiosensitization is independent of the radioprotection produced by DMSO.

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Year:  1978        PMID： 277231      PMCID： PMC2149389     

Source DB:  PubMed          Journal:  Br J Cancer Suppl        ISSN： 0306-9443


  8 in total

1.  Selective radiosensitization of the hypoxic cells of mouse tumors with the nitroimidazoles metronidazole and Ro 7-0582.

Authors:  J M Brown
Journal:  Radiat Res       Date:  1975-12       Impact factor: 2.841

2.  Dose-time relationships for skin reactions and structural damage in rat feet exposed to 250-kVp x rays.

Authors:  J E Moulder; J J Fischer; A Casey
Journal:  Radiology       Date:  1975-05       Impact factor: 11.105

3.  Combined use of radioprotective and radiosensitizing drugs in experimental radiotherapy.

Authors:  J M Yuhas; M Yurconic; M M Kligerman; G West; D F Peterson
Journal:  Radiat Res       Date:  1977-05       Impact factor: 2.841

4.  Time-dose relationships for the cure of an experimental rat tumor with fractionated radiation.

Authors:  J E Moulder; J J Fischer; R Milardo
Journal:  Int J Radiat Oncol Biol Phys       Date:  1976 Mar-Apr       Impact factor: 7.038

5.  Tumour cure rate and cell survival of a transplantable rat rhabdomyosarcoma following x-irradiation.

Authors:  H S Reinhold; C De Bree
Journal:  Eur J Cancer       Date:  1968-08       Impact factor: 9.162

6.  Effects of dimethyl sulfoxide and hypoxic cell radiosensitizers on the radiation response of the KHT murine tumor in vivo.

Authors:  A M Rauth; J E Paciga
Journal:  Radiat Res       Date:  1977-02       Impact factor: 2.841

7.  Quantitative evaluation of the radiosensitivity of cells of a transplantable rhabdomyosarcoma in the rat.

Authors:  H S Reinhold
Journal:  Eur J Cancer       Date:  1966-02       Impact factor: 9.162

8.  Effect of the radioprotective drugs MEA, DMSO, and WR-2721 on tumor control and skin tolerance in the rat.

Authors:  J E Moulder; P S Lo; J J Fischer
Journal:  Cancer Treat Rep       Date:  1977-08
  8 in total
  1 in total

1.  Tumour response endpoints in the BA1112 rat sarcoma.

Authors:  D F Martin; J E Moulder; J J Fischer
Journal:  Br J Cancer Suppl       Date:  1980-04
  1 in total

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