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Literature DB >> 277228

Testing of hypoxic cell radiosensitizers in vivo.

Abstract

Use has been made of the transplantable KHT sarcoma in C3H mice to test the in vivo effectiveness of some 2-, 4-, and 5-nitroimidazoles as hypoxic cell radiosensitizers. A comparison of the in vivo versus the in vitro sensitizing ability of misonidazole and metronidazole indicates some differences, probably due to drug delivery problems in vivo. The relative sensitizing abilities of eight 2-nitroimidazoles, two 4-nigroimidazoles and two 5-nitroimidazoles are compared on the basis of the amount of drug injected and the plasma levels obtained.

Entities: Chemical Disease Species

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Year: 1978 PMID： 277228 PMCID： PMC2149425

Source DB: PubMed Journal: Br J Cancer Suppl ISSN： 0306-9443

6 in total

1. Radiosensitizers of hypoxic cells in solid tumors.

Authors: J F Fowler; G E Adams; J Denekamp
Journal: Cancer Treat Rev Date: 1976-12 Impact factor: 12.111

2. Selective radiosensitization of the hypoxic cells of mouse tumors with the nitroimidazoles metronidazole and Ro 7-0582.

Authors: J M Brown
Journal: Radiat Res Date: 1975-12 Impact factor: 2.841

3. Effects of dimethyl sulfoxide and hypoxic cell radiosensitizers on the radiation response of the KHT murine tumor in vivo.

Authors: A M Rauth; J E Paciga
Journal: Radiat Res Date: 1977-02 Impact factor: 2.841

4. Metronidazole: effect on radiosensitivity of tumor and normal tissues in mice.

Authors: H B Stone; H R Withers
Journal: J Natl Cancer Inst Date: 1975-11 Impact factor: 13.506

5. In vivo testing of hypoxic radiosensitizers using the KHT murine tumour assayed by the lung-colony technique.

Authors: A M Rauth; K Kaufman
Journal: Br J Radiol Date: 1975-03 Impact factor: 3.039

6. Electron-affinic sensitization. VII. A correlation between structures, one-electron reduction potentials, and efficiencies of nitroimidazoles as hypoxic cell radiosensitizers.

Authors: G E Adams; I R Flockhart; C E Smithen; I J Stratford; P Wardman; M E Watts
Journal: Radiat Res Date: 1976-07 Impact factor: 2.841

6 in total

8 in total

1. Radiosynthesis of the tumor hypoxia marker [18F]TFMISO via O-[18F]trifluoroethylation reveals a striking difference between trifluoroethyl tosylate and iodide in regiochemical reactivity toward oxygen nucleophiles.

Authors: Makiko Suehiro; Guangbin Yang; Geralda Torchon; Ellen Ackerstaff; John Humm; Jason Koutcher; Ouathek Ouerfelli
Journal: Bioorg Med Chem Date: 2011-02-18 Impact factor: 3.641

Testing of hypoxic cell radiosensitizers in vivo.

1. Radiosensitizers of hypoxic cells in solid tumors.

2. Selective radiosensitization of the hypoxic cells of mouse tumors with the nitroimidazoles metronidazole and Ro 7-0582.

3. Effects of dimethyl sulfoxide and hypoxic cell radiosensitizers on the radiation response of the KHT murine tumor in vivo.

4. Metronidazole: effect on radiosensitivity of tumor and normal tissues in mice.

5. In vivo testing of hypoxic radiosensitizers using the KHT murine tumour assayed by the lung-colony technique.

6. Electron-affinic sensitization. VII. A correlation between structures, one-electron reduction potentials, and efficiencies of nitroimidazoles as hypoxic cell radiosensitizers.

1. Radiosynthesis of the tumor hypoxia marker [18F]TFMISO via O-[18F]trifluoroethylation reveals a striking difference between trifluoroethyl tosylate and iodide in regiochemical reactivity toward oxygen nucleophiles.

2. Structure-pharmacokinetic relationships for misonidazole analogues in mice.

3. The effect of misonidazole in combination with radiation dose fractionation.

4. Pharmacokinetic considerations in testing hypoxic cell radiosensitizers in mouse tumours.

5. Studies of the in vivo and in vitro cytotoxicity of the drug RSU-1069.

6. In vivo combination of misonidazole and the chemotherapeutic agent CCNU.

7. Ascorbate anion potentiates cytotoxicity of nitro-aromatic compounds under hypoxic and anoxic conditions.

8. A phase I study of misonidazole and pelvic irradiation in patients with carcinoma of cervix.