Literature DB >> 277227

Effect of radiation on cis-dichlorodiammineplatinum (II) and DNA in aqueous solution.

R C Richmond, M G Simic.   

Abstract

The radiolysis of cis-dichlorodiammineplatinum (II) (cis-PDD) was studied in order to better understand the mechanisms by which it acts as a radiation sensitizer. The Pt(I) intermediate formed by e- aq reduction of cis-PDD loses both chlorides rapidly, interacts with O2 to form a Pt-oxygen adduct, reacts with the hydroxyl radical adduct of thymine and the peroxy radical of t-butanol, and disproportionates to platinum metal and trans-PDD. The Pt (III) intermediate formed by OH oxidation of cis-PDD likely disproportionates to cis-PDD and Pt(IV) complexes. In a biological model, radiation-induced 3H-thymine base residue release from DNA is found to be inhibited by cis-PDD.

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Year:  1978        PMID： 277227      PMCID： PMC2149397     

Source DB:  PubMed          Journal:  Br J Cancer Suppl        ISSN： 0306-9443


  9 in total

1.  In vivo radiation-induced thymine residue release from Escherichia coli DNA.

Authors:  R C Richmond; J D Zimbrick
Journal:  Biochem Biophys Res Commun       Date:  1975-05-05       Impact factor: 3.575

2.  Strand breaks, base release, and postirradiation changes in DNA gamma-irradiated in dilute O2-saturated aqueous solution.

Authors:  J F Ward; I Kuo
Journal:  Radiat Res       Date:  1976-06       Impact factor: 2.841

3.  Radiation-induced DNA damage and lethality in E. coli as modified by the antitumor agent cis-dichlorodiammineplatinum (II).

Authors:  R C Richmond; J D Zimbrick; D L Hykes
Journal:  Radiat Res       Date:  1977-08       Impact factor: 2.841

4.  Interactions between mammalian cell DNA and inorganic platinum compounds. II. Interstrand cross-linking of isolated and cellular DNA by platinum(IV) compounds.

Authors:  J M Pascoe; J J Roberts
Journal:  Biochem Pharmacol       Date:  1974-05-01       Impact factor: 5.858

5.  Addition of hydroxyl radicals to pyrimidine bases and electron transfer reactions of intermediates to quinones.

Authors:  E Hayon; M Simic
Journal:  J Am Chem Soc       Date:  1973-02-21       Impact factor: 15.419

6.  Radiation sensitization of bacterial spores by cis-dichlorodiammineplatinum(II).

Authors:  R C Richmond; E L Powers
Journal:  Radiat Res       Date:  1976-11       Impact factor: 2.841

Review 7.  Platinum coordination complexes in cancer chemotherapy.

Authors:  B Rosenberg
Journal:  Naturwissenschaften       Date:  1973-09

8.  Interaction of cis-dichlorodiammineplatinum (II) with DNA.

Authors:  P Horácek; J Drobník
Journal:  Biochim Biophys Acta       Date:  1971-12-16

9.  A paper chromatographic study on some platinum (II) compounds. II. The separation of cis- and trans-dihalogenodiammineplatinum (II) complexes.

Authors:  F BASOLO; M LEDERER; L OSSICINI; K H STEPHEN
Journal:  J Chromatogr       Date:  1963-03
  9 in total
  3 in total

1.  Radiosensitization of DNA by Cisplatin Adducts Results from an Increase in the Rate Constant for the Reaction with Hydrated Electrons and Formation of Pt(I).

Authors:  B Behmand; J-L Marignier; M Mostafavi; J R Wagner; D J Hunting; L Sanche
Journal:  J Phys Chem B       Date:  2015-07-09       Impact factor: 2.991

2.  Cisplatin intrastrand adducts sensitize DNA to base damage by hydrated electrons.

Authors:  B Behmand; J R Wagner; L Sanche; D J Hunting
Journal:  J Phys Chem B       Date:  2014-04-29       Impact factor: 2.991

3.  Concurrent chemoradiotherapy with intravenous cisplatin and docetaxel for advanced oral cancer.

Authors:  Kotaro Sato; Yasushi Hayashi; Kazuyo Watanabe; Ryoko Yoshimi; Hideharu Hibi
Journal:  Nagoya J Med Sci       Date:  2019-08       Impact factor: 1.131
  3 in total

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