Literature DB >> 27722545

Enolate-mediated 1,3-dipolar cycloaddition reactions of allyl ketones with nitrile oxides: direct access to 3,5-disubstituted isoxazolines.

Wenjun Li1, Xiao Zhou1, Zhenyan Shi1, Yang Liu1, Zhantao Liu1, Hua Gao1.   

Abstract

TMG-promoted [3 + 2] organocatalytic 1,3-dipolar cycloaddition reactions of allyl ketones with in situ generated nitrile oxides have been developed. This strategy could generate 3,5-disubstituted isoxazolines in high yields and regioselectivities.

Entities:  

Year:  2016        PMID： 27722545     DOI： 10.1039/c6ob02025a

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  2 in total

1.  Synthesis of 3,4,5-trisubstituted isoxazoles in water via a [3 + 2]-cycloaddition of nitrile oxides and 1,3-diketones, β-ketoesters, or β-ketoamides.

Authors:  Md Imran Hossain; Md Imdadul H Khan; Seong Jong Kim; Hoang V Le
Journal:  Beilstein J Org Chem       Date:  2022-04-22       Impact factor: 2.544

2.  Facile synthesis of O-acylhydroxamates via reaction of oxime chlorides with carboxylic acids.

Authors:  Kai-Kai Wang; Yan-Li Li; Ying-Chao Zhao; Shan-Shan Zhang; Rongxiang Chen; Aili Sun
Journal:  RSC Adv       Date:  2021-12-20       Impact factor: 3.361
  2 in total

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