Literature DB >> 27722495

Nuclease activity as a specific biomarker for breast cancer.

Luiza I Hernandez1, Veli Cengiz Ozalp, Frank J Hernandez.   

Abstract

We report on the activity of nucleases derived from cancer cells as a means for specific targeting using nucleic acid probes (substrates). We hypothesize that cancer cells can be differentiated from healthy cells based on their nuclease activity profile, and thus, any method based on this property represents a novel alternative for diagnostic and therapeutic intervention.

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Year:  2016        PMID： 27722495     DOI： 10.1039/c6cc07108b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

1.  Expanding the Toolbox for Label-Free Enzyme Assays: A Dinuclear Platinum(II) Complex/DNA Ensemble with Switchable Near-IR Emission.

Authors:  Moustafa T Gabr; F Christopher Pigge
Journal:  Molecules       Date:  2019-12-01       Impact factor: 4.411

2.  Rational Design and Experimental Analysis of Short-Oligonucleotide Substrate Specificity for Targeting Bacterial Nucleases.

Authors:  Tania Jiménez; Juliana Botero; Dorleta Otaegui; Javier Calvo; Frank J Hernandez; Eider San Sebastian
Journal:  J Med Chem       Date:  2021-08-30       Impact factor: 7.446

3.  Optical sensor revealed abnormal nuclease spatial activity on cancer cell membrane.

Authors:  Yongliang Wang; Yuanchang Zhao; Anwesha Sarkar; Xuefeng Wang
Journal:  J Biophotonics       Date:  2019-01-28       Impact factor: 3.207
  3 in total

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