| Literature DB >> 27722485 |
Sumaira Ashraf1, Joonhyuck Park2, Mathilde A Bichelberger3, Karsten Kantner1, Raimo Hartmann1, Pauline Maffre3, Alaa Hassan Said4, Neus Feliu1, Junhwa Lee2, Dakyeon Lee5, Gerd Ulrich Nienhaus6, Sungjee Kim2, Wolfgang J Parak1.
Abstract
We have studied the effect of the zwitterionic surface coating of quantum dots (QDs) on their interaction with a serum supplemented cell medium and their internalization by human cervical carcinoma (HeLa) cells. Zwitterionic QDs showed negligible adsorption of human serum albumin (HSA) selected as a model serum protein, in contrast to similar but negatively charged QDs. The incorporation of zwitterionic QDs by HeLa cells was found to be lower than for negatively charged QDs and for positively charged QDs, for which the uptake yield was largest. Our results suggest that the suppression of protein adsorption, here accomplished by zwitterionic QD surfaces, offers a strategy that allows for reducing the cellular uptake of nanoparticles.Entities:
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Year: 2016 PMID： 27722485 DOI： 10.1039/c6nr05805a
Source DB: PubMed Journal: Nanoscale ISSN： 2040-3364 Impact factor: 7.790