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Literature DB >> 277220

Cytotoxicity of radiosensitizers in multicell spheroids: combination treatment with hyperthermia.

Abstract

Spheroids of EMT6 tumour cells were grown in spinner culture. As with V79 cell spheroids, the combination of 1.5mM misonidazole and hyperthermia at 42.5 degree C for 1 or 2 h cuased greater cytotoxicity than either heat or drug alone. Radioresistant hypoxic cells at the centre of the spheroids were eliminated but other cells were also killed.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1978 PMID： 277220 PMCID： PMC2149386

Source DB: PubMed Journal: Br J Cancer Suppl ISSN： 0306-9443

16 in total

1. Cytotoxicity of two nitroimidazole radiosensitizers in an in vitro tumor model.

Authors: R Sridhar; C Koch; R Suterland
Journal: Int J Radiat Oncol Biol Phys Date: 1976 Nov-Dec Impact factor: 7.038

2. Hyperthermic potentiation of cytotoxicity of Ro-07-0582 in multicell spheroids.

Authors: R Sridhar; R Sutherland
Journal: Int J Radiat Oncol Biol Phys Date: 1977 May-Jun Impact factor: 7.038

3. Ro-07-0582 as a radiosensitizer and cytotoxic agent.

Authors: E J Hall; J Biaglow
Journal: Int J Radiat Oncol Biol Phys Date: 1977 May-Jun Impact factor: 7.038

4. Letter: Modification of the radiation response of an in vitro tumour model by control of cellular respiration.

Authors: R E Durand; J E Biaglow
Journal: Int J Radiat Biol Relat Stud Phys Chem Med Date: 1974-12

5. Metabolic aspects of the role of hyperthermia im mammalian cell inactivation and their possible relevance to cancer treatment.

Authors: G M Hahn
Journal: Cancer Res Date: 1974-11 Impact factor: 12.701

6. Selective chemotherapy of noncycling cells in an in vitro tumor model.

Authors: R M Sutherland
Journal: Cancer Res Date: 1974-12 Impact factor: 12.701

7. Radiosensitization by nifuroxime of the hypoxic cells in an in vitro tumour model.

Authors: R M Sutherland; R E Durand
Journal: Int J Radiat Biol Relat Stud Phys Chem Med Date: 1972-12

8. Effect of hyperthermia on differential cytotoxicity of a hypoxic cell radiosensitizer, Ro-07-0582, on mammalian cells in vitro.

Authors: I J Stratford; G E Adams
Journal: Br J Cancer Date: 1977-03 Impact factor: 7.640

Cytotoxicity of radiosensitizers in multicell spheroids: combination treatment with hyperthermia.

1. Cytotoxicity of two nitroimidazole radiosensitizers in an in vitro tumor model.

2. Hyperthermic potentiation of cytotoxicity of Ro-07-0582 in multicell spheroids.

3. Ro-07-0582 as a radiosensitizer and cytotoxic agent.

4. Letter: Modification of the radiation response of an in vitro tumour model by control of cellular respiration.

5. Metabolic aspects of the role of hyperthermia im mammalian cell inactivation and their possible relevance to cancer treatment.

6. Selective chemotherapy of noncycling cells in an in vitro tumor model.

7. Radiosensitization by nifuroxime of the hypoxic cells in an in vitro tumour model.

8. Effect of hyperthermia on differential cytotoxicity of a hypoxic cell radiosensitizer, Ro-07-0582, on mammalian cells in vitro.

9. Interaction of hyperthermia and the hypoxic cell sensitizer Ro-07-0582 on the EMT6 mouse tumour.

10. Metronidazole (Flagyl): characterization as a cytotoxic drug specific for hypoxic tumour cells.

1. Three-dimensional neuroblastoma cell culture: proteomic analysis between monolayer and multicellular tumor spheroids.

Review 2. Multicellular spheroids. A review on cellular aggregates in cancer research.

Review 3. Therapeutic response differences between 2D and 3D tumor models of magnetic hyperthermia.