Ritika R Harjani1, Janaki Manur Gururajachar2, Umamaheswari Krishnaswamy3. 1. Department of Radiation Oncology, Gujarat Cancer & Research Institute, Ahmedabad, India. 2. Department of Radiation Oncology, M.S. Ramaiah Medical College, Bangalore, India. 3. Department of Pulmonary Medicine, St. John's National Academy of Health Sciences, Bangalore, India.
Abstract
AIM: The aim of this prospective study was to assess Somnolence Syndrome (SS) in patients undergoing radiation to the brain. BACKGROUND: SS is one of the sequelae of radiation to the brain, which is observed within three months of radiation. This is a self-limiting condition and a failure to diagnose leads to unnecessary investigations. This study was undertaken to objectively and subjectively analyze the occurrence, clinical presentation and severity of SS. MATERIALS AND METHODS: Thirty-three patients receiving radiation to the brain were included in the study. Visual Analog Scale (VAS) was used for subjective assessment and the Littman Somnolence Syndrome (LSS) scale was used for objective assessment of SS. Sleep Latency Test (SLT) was used to quantify SS. RESULTS: VAS scores showed an initial fall until week 3, followed by a plateau and a sudden increase after week 10. LSS scale at week 11 and 12 showed that 13 patients (43.3%) had grade 2, 5 (16.7%) had grade 3; and 2 (6.7%) had grade 4 SS. SLT revealed a shift of predominant sleep pattern from NREM 1 to NREM 2 at 6 weeks after radiation with a p value of 0.0412. CONCLUSIONS: An insight into SS, its features, frequency of occurrence and self limiting nature can prevent anxiety and unwarranted investigations in the immediate post radiation period.
AIM: The aim of this prospective study was to assess Somnolence Syndrome (SS) in patients undergoing radiation to the brain. BACKGROUND: SS is one of the sequelae of radiation to the brain, which is observed within three months of radiation. This is a self-limiting condition and a failure to diagnose leads to unnecessary investigations. This study was undertaken to objectively and subjectively analyze the occurrence, clinical presentation and severity of SS. MATERIALS AND METHODS: Thirty-three patients receiving radiation to the brain were included in the study. Visual Analog Scale (VAS) was used for subjective assessment and the Littman Somnolence Syndrome (LSS) scale was used for objective assessment of SS. Sleep Latency Test (SLT) was used to quantify SS. RESULTS: VAS scores showed an initial fall until week 3, followed by a plateau and a sudden increase after week 10. LSS scale at week 11 and 12 showed that 13 patients (43.3%) had grade 2, 5 (16.7%) had grade 3; and 2 (6.7%) had grade 4 SS. SLT revealed a shift of predominant sleep pattern from NREM 1 to NREM 2 at 6 weeks after radiation with a p value of 0.0412. CONCLUSIONS: An insight into SS, its features, frequency of occurrence and self limiting nature can prevent anxiety and unwarranted investigations in the immediate post radiation period.
Authors: P Littman; J Rosenstock; G Gale; R E Krisch; A Meadows; H Sather; P Coccia; B DeCamargo Journal: Int J Radiat Oncol Biol Phys Date: 1984-10 Impact factor: 7.038
Authors: Cerri Powell; Douglas Guerrero; Susan Sardell; Sebastian Cumins; Beverley Wharram; Daphne Traish; Adam Gonsalves; Sue Ashley; Michael Brada Journal: Radiother Oncol Date: 2011-07-23 Impact factor: 6.280
Authors: J Jacob; L Feuvret; J-M Simon; M Ribeiro; L Nichelli; C Jenny; D Ricard; D Psimaras; K Hoang-Xuan; P Maingon Journal: Neurol Sci Date: 2022-02-11 Impact factor: 3.307