BACKGROUND: We evaluated Gamma Knife radiosurgery (GKRS) as a treatment option for patients with recurrent glioblastoma. PATIENTS AND METHODS: 42 patients with histopathologically diagnosed recurrent grade IV tumor were treated with GKRS. All patients had undergone standard multimodal first-line treatment. The average time from diagnosis to GKRS was 17.0 months. The median target volume was 5.1 cm3. The median margin dose was 10 Gy and the median central dose 20 Gy. In a subset of patients, O6-methylguanine methyltransferase (MGMT) promoter methylation analysis by pyrosequencing was performed. RESULTS: Most patients did not develop complications after GKRS. Time to radiological progression after initial GKRS was 4.4 months (95% CI: 3.1-5.7 months). Radiological progression mainly occurred beyond the GKRS-irradiated area. The median survival time after initial GKRS was 9.6 months (95% CI: 7.7-11.5 months). The median overall survival time from diagnosis was 25.6 months (95% CI: 21.8-29.3 months). Patients with MGMT promoter methylation survived significantly longer (33.4 months; 95% CI: 21.2-45.5 months) compared to patients without MGMT promoter methylation (16.0 months; 95% CI: 8.0-23.9 months). CONCLUSION: GKRS seems to be a relatively safe salvage treatment option for recurrent glioblastoma for highly selected patients but must be seen as part of a multimodal treatment algorithm.
BACKGROUND: We evaluated Gamma Knife radiosurgery (GKRS) as a treatment option for patients with recurrent glioblastoma. PATIENTS AND METHODS: 42 patients with histopathologically diagnosed recurrent grade IV tumor were treated with GKRS. All patients had undergone standard multimodal first-line treatment. The average time from diagnosis to GKRS was 17.0 months. The median target volume was 5.1 cm3. The median margin dose was 10 Gy and the median central dose 20 Gy. In a subset of patients, O6-methylguanine methyltransferase (MGMT) promoter methylation analysis by pyrosequencing was performed. RESULTS: Most patients did not develop complications after GKRS. Time to radiological progression after initial GKRS was 4.4 months (95% CI: 3.1-5.7 months). Radiological progression mainly occurred beyond the GKRS-irradiated area. The median survival time after initial GKRS was 9.6 months (95% CI: 7.7-11.5 months). The median overall survival time from diagnosis was 25.6 months (95% CI: 21.8-29.3 months). Patients with MGMT promoter methylation survived significantly longer (33.4 months; 95% CI: 21.2-45.5 months) compared to patients without MGMT promoter methylation (16.0 months; 95% CI: 8.0-23.9 months). CONCLUSION: GKRS seems to be a relatively safe salvage treatment option for recurrent glioblastoma for highly selected patients but must be seen as part of a multimodal treatment algorithm.
Authors: Seung Won Choi; Kyung Rae Cho; Jung Won Choi; Doo-Sik Kong; Ho Jun Seol; Do-Hyun Nam; Jung-Il Lee Journal: J Neurooncol Date: 2019-11-08 Impact factor: 4.130
Authors: Adomas Bunevicius; Stylianos Pikis; Douglas Kondziolka; Dev N Patel; Kenneth Bernstein; Erik P Sulman; Cheng-Chia Lee; Huai-Che Yang; Violaine Delabar; David Mathieu; Christopher P Cifarelli; David E Arsanious; Basem A Dahshan; Joshua S Weir; Herwin Speckter; Angel Mota; Manjul Tripathi; Narendra Kumar; Ronald E Warnick; Selcuk Peker; Yavuz Samanci; Gene Barnett; Farid El Hefnawi; Ghusn Al Sideiri; Jason Sheehan Journal: J Neurooncol Date: 2021-11-19 Impact factor: 4.130
Authors: Alireza Feli; Shima Jazayeri; Mohammad Ali Bitaraf; Masoud Solaymani Dodaran; Karim Parastouei; Mohammad Javad Hosseinzadeh-Attar Journal: Asian Pac J Cancer Prev Date: 2017-07-27
Authors: Roel G W Verhaak; Sun Ha Paek; Yona Kim; Frederick S Varn; Sung-Hye Park; Byung Woo Yoon; Hye Ran Park; Charles Lee Journal: Acta Neuropathol Commun Date: 2021-03-24 Impact factor: 7.801