Literature DB >> 27721295

Acute myeloid leukemia with t(4;12)(q12;p13): A morphological dilemma.

Umang V Patel1, S R Arun1, Deepak Kumar Mishra2, Mayur Parihar1.   

Abstract

Cytogenetics has a pivotal role in risk stratification of acute myeloid leukemia (AML). We report a case of AML with a t(4;12)(q12;p13). To the best of our knowledge, there are about 24 cases of t(4;12) reported in AML which are usually misdiagnosed as lymphoproliferative disorders on morphological assessment. This case showed specific clinical, morphological, and immunophenotypic features such as (1) pseudo lymphoid morphology, (2) dysplasia in granulocytic series, (3) an immature immunophenotype with positivity for CD34 and CD117, and (4) poor treatment response.

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Year:  2016        PMID： 27721295     DOI： 10.4103/0377-4929.191814

Source DB:  PubMed          Journal:  Indian J Pathol Microbiol        ISSN： 0377-4929            Impact factor:   0.740


  3 in total

1.  Myeloid malignancies with translocation t(4;12)(q11-13;p13): molecular landscape, clonal hierarchy and clinical outcomes.

Authors:  Vincent Parinet; Elise Chapiro; Audrey Bidet; Baptiste Gaillard; Odile Maarek; Laurence Simon; Christine Lefebvre; Sabine Defasque; Marie-Joelle Mozziconacci; Anne Quinquenel; Matthieu Decamp; François Lifermann; Nadia Ali-Ammar; Agathe Maillon; Marine Baron; Mélanie Martin; Stéphanie Struski; Dominique Penther; Jean-Baptiste Micol; Nathalie Auger; Chrystèle Bilhou-Nabera; Jean-Alain Martignoles; Sylvie Tondeur; Florence Nguyen-Khac; Pierre Hirsch; Damien Roos-Weil
Journal:  J Cell Mol Med       Date:  2021-09-07       Impact factor: 5.310

2.  Acute myeloid leukemia with t(4;12)(q12;p13): an aggressive disease with frequent involvement of PDGFRA and ETV6.

Authors:  Jingyi Li; Jie Xu; Lynne V Abruzzo; Guilin Tang; Shaoying Li; M James You; Gary Lu; Elias J Jabbour; Qi Deng; Carlos E Bueso-Ramos; L Jeffrey Medeiros; C Cameron Yin
Journal:  Oncotarget       Date:  2017-12-15

3.  Acute myeloid leukemia with t(4;12)(q12;p13) treated with an allogeneic stem cell transplant: A case report and review of the literature.

Authors:  Christie Hancock; Dimitra Kanaloupitis; Ronald Sirota; Jillene Kogan; Leonard Klein; John Eklund
Journal:  Leuk Res Rep       Date:  2018-05-06
  3 in total

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