Yang Zhao1, Xuli Wang2, Yanrong Wang3. 1. Department of Chinese and Western Medicine, Tianjin Fourth Center Hospital (Tianjin Medical University Fourth Center Clinical College), Tianjin 300140, P.R. China. 2. Department of Hematology-Oncology, Tianjin Fourth Center Hospital (Tianjin Medical University Fourth Center Clinical College), Tianjin 300140, P.R. China. 3. Department of Gastroenterology, Tianjin Fourth Center Hospital (Tianjin Medical University Fourth Center Clinical College), Tianjin 300140, P.R. China.
Abstract
OBJECTIVE: Helicobacter pylori infection and colorectal cancer risk are not clear. We perform this meta-analysis to further evaluate the association between H. pylori infection and colorectal cancer susceptibility. METHODS: The databases of CNKI, Wanfang, PubMed, Medline, EMBASE, and HighWire Press were electronic searched by two reviewers independently. The case-control study or cohort study about H. pylori infection and colorectal cancer risk were included in this meta-analysis. The association between H. pylori infection and colorectal cancer risk was evaluated by odds ratio (OR) and corresponding 95% confidence interval (95% CI). RESULTS: Fourteen case-control studies related to H. pylori infection and colorectal cancer risk were eventually include in this meta-analysis. The pooled results showed that H. pylori infection slight increase the risk of developing colorectal carcinoma (OR = 1.33, 95% CI: 1.01-1.77, P = 0.05). Moreover, Begg's funnel plot demonstrated no significant publication bias. CONCLUSION: Colorectal carcinoma is associated with H. pylori infection. However, for significant heterogeneity across the studies, this results should be further confirmed by large sample size cohort study.
OBJECTIVE:Helicobacter pyloriinfection and colorectal cancer risk are not clear. We perform this meta-analysis to further evaluate the association between H. pyloriinfection and colorectal cancer susceptibility. METHODS: The databases of CNKI, Wanfang, PubMed, Medline, EMBASE, and HighWire Press were electronic searched by two reviewers independently. The case-control study or cohort study about H. pyloriinfection and colorectal cancer risk were included in this meta-analysis. The association between H. pyloriinfection and colorectal cancer risk was evaluated by odds ratio (OR) and corresponding 95% confidence interval (95% CI). RESULTS: Fourteen case-control studies related to H. pyloriinfection and colorectal cancer risk were eventually include in this meta-analysis. The pooled results showed that H. pyloriinfection slight increase the risk of developing colorectal carcinoma (OR = 1.33, 95% CI: 1.01-1.77, P = 0.05). Moreover, Begg's funnel plot demonstrated no significant publication bias. CONCLUSION:Colorectal carcinoma is associated with H. pyloriinfection. However, for significant heterogeneity across the studies, this results should be further confirmed by large sample size cohort study.
Authors: Julia Butt; Matthew G Varga; William J Blot; Lauren Teras; Kala Visvanathan; Loïc Le Marchand; Christopher Haiman; Yu Chen; Ying Bao; Howard D Sesso; Sylvia Wassertheil-Smoller; Gloria Y F Ho; Lesley E Tinker; Richard M Peek; John D Potter; Timothy L Cover; Laura H Hendrix; Li-Ching Huang; Terry Hyslop; Caroline Um; Francine Grodstein; Mingyang Song; Anne Zeleniuch-Jacquotte; Sonja Berndt; Allan Hildesheim; Tim Waterboer; Michael Pawlita; Meira Epplein Journal: Gastroenterology Date: 2018-10-06 Impact factor: 22.682
Authors: Meira Epplein; Loïc Le Marchand; Timothy L Cover; Mingyang Song; William J Blot; Richard M Peek; Lauren R Teras; Kala Visvanathan; Yu Chen; Howard D Sesso; Anne Zeleniuch-Jacquotte; Sonja I Berndt; John D Potter; Marc D Ryser; Christopher A Haiman; Sylvia Wassertheil-Smoller; Lesley F Tinker; Tim Waterboer; Julia Butt Journal: Microorganisms Date: 2020-10-30