Yoon Soo Kyung1, Dalsan You2, In Gab Jeong2, Seungbong Han3, Hong-Kyu Kim1, Choung-Soo Kim4. 1. Department of Health Screening and Promotion Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. 2. Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. 3. Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. 4. Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address: cskim@amc.seoul.kr.
Abstract
OBJECTIVE: To evaluate the relationship between changes in weight, waist circumference (WC), metabolic syndrome (MetS), and prostate growth over 5 years in the adult population. MATERIALS AND METHODS: Data were collected from 1088 adult men (age ≥40 years) without history of prostate cancer who underwent more than 2 general health screenings between 2006 and 2013. Percent changes in prostate volume (PV) were assessed for 5 years after baseline measurements. Associations between prostate growth and change in weight, WC and MetS status, respectively, were calculated using uni- and multivariate linear regression analyses. RESULTS: During the 5 years, the median PV changes were 1.3 cc/year corresponding to a median growth rate of 6.2%/year. By multivariate linear regression analysis, change in weight was significantly associated with prostate growth (P < .01) after adjusting for age, initial PV, and initial body mass index (BMI). Prostate growth and weight changes were correlated in obese men (initial BMI ≥ 25 kg/m2) (0.150; 95% confidence interval [CI], 0.425-1.547; P <.01) but not in nonobese men (initial BMI < 25 kg/m2) (0.054; 95% CI, -0.176 to 0. 858; P = .20). Patients with newly developed MetS showed greater prostate growth than those who did not have MetS (6.796; 95% CI, 1.599-12.003; P = .01). CONCLUSION: Changes in weight, WC and newly diagnosed MetS affected prostate growth rate during 5 years. Reducing weight and controlling MetS could decrease the prostate growth rate.
OBJECTIVE: To evaluate the relationship between changes in weight, waist circumference (WC), metabolic syndrome (MetS), and prostate growth over 5 years in the adult population. MATERIALS AND METHODS: Data were collected from 1088 adult men (age ≥40 years) without history of prostate cancer who underwent more than 2 general health screenings between 2006 and 2013. Percent changes in prostate volume (PV) were assessed for 5 years after baseline measurements. Associations between prostate growth and change in weight, WC and MetS status, respectively, were calculated using uni- and multivariate linear regression analyses. RESULTS: During the 5 years, the median PV changes were 1.3 cc/year corresponding to a median growth rate of 6.2%/year. By multivariate linear regression analysis, change in weight was significantly associated with prostate growth (P < .01) after adjusting for age, initial PV, and initial body mass index (BMI). Prostate growth and weight changes were correlated in obesemen (initial BMI ≥ 25 kg/m2) (0.150; 95% confidence interval [CI], 0.425-1.547; P <.01) but not in nonobese men (initial BMI < 25 kg/m2) (0.054; 95% CI, -0.176 to 0. 858; P = .20). Patients with newly developed MetS showed greater prostate growth than those who did not have MetS (6.796; 95% CI, 1.599-12.003; P = .01). CONCLUSION: Changes in weight, WC and newly diagnosed MetS affected prostate growth rate during 5 years. Reducing weight and controlling MetS could decrease the prostate growth rate.