Wilson Sui1, Arindam RoyChoudhury2, Sven Wenske1, Guarionex J Decastro1, James M McKiernan1, Christopher B Anderson3. 1. Department of Urology, Columbia University Medical Center, New York, NY. 2. Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY. 3. Department of Urology, Columbia University Medical Center, New York, NY. Electronic address: cba2125@cumc.columbia.edu.
Abstract
OBJECTIVE: To identify prognostic and treatment factors for primary urethral cancer using a nationwide database. MATERIALS AND METHODS: The National Cancer Database was queried for all cases of primary urethral cancer from 2004 to 2013. Patients with other cancer diagnoses, metastasis, or diagnosis on autopsy were excluded. Proportional hazards regression was used to identify independent predictors of overall survival in patients with primary urethral cancer. Because we hypothesized that predictors may covary by sex, we also performed regression analysis stratified by sex. RESULTS: We identified 1268 men and 869 women with primary urethral cancer. Women tended to have more advanced tumors and adenocarcinoma histology. Median survival for the entire cohort was 49 months (43-55), with 5- and 10-year survival rates of 46% and 31%, respectively. On multivariate analysis, age, race, stage, grade, and Charlson comorbidity index were independent predictors of overall survival. Histology was not a predictor of overall survival in the combined model; however, adenocarcinoma in women increased hazards of death, whereas it decreased hazards of death in men when compared with squamous cell carcinoma. CONCLUSION: Men and women with primary urethral cancer had significant differences in histology, grade, and nodal status. In addition to several expected disease-related factors, black race was associated with increased mortality for patients with primary urethral cancer.
OBJECTIVE: To identify prognostic and treatment factors for primary urethral cancer using a nationwide database. MATERIALS AND METHODS: The National Cancer Database was queried for all cases of primary urethral cancer from 2004 to 2013. Patients with other cancer diagnoses, metastasis, or diagnosis on autopsy were excluded. Proportional hazards regression was used to identify independent predictors of overall survival in patients with primary urethral cancer. Because we hypothesized that predictors may covary by sex, we also performed regression analysis stratified by sex. RESULTS: We identified 1268 men and 869 women with primary urethral cancer. Women tended to have more advanced tumors and adenocarcinoma histology. Median survival for the entire cohort was 49 months (43-55), with 5- and 10-year survival rates of 46% and 31%, respectively. On multivariate analysis, age, race, stage, grade, and Charlson comorbidity index were independent predictors of overall survival. Histology was not a predictor of overall survival in the combined model; however, adenocarcinoma in women increased hazards of death, whereas it decreased hazards of death in men when compared with squamous cell carcinoma. CONCLUSION:Men and women with primary urethral cancer had significant differences in histology, grade, and nodal status. In addition to several expected disease-related factors, black race was associated with increased mortality for patients with primary urethral cancer.
Authors: Roy Mano; Emily A Vertosick; Joseph Sarcona; Daniel D Sjoberg; Nicole E Benfante; Timothy F Donahue; Harry W Herr; S Machele Donat; Bernard H Bochner; Guido Dalbagni; Alvin C Goh Journal: BJU Int Date: 2020-06-04 Impact factor: 5.588
Authors: Mierxiati Abudurexiti; Jun Wang; Ning Shao; Fang-Ning Wan; Yao Zhu; Bo Dai; Ding-Wei Ye Journal: Cancer Manag Res Date: 2018-12-07 Impact factor: 3.989
Authors: Isabelle Antwerpen; Lukas Gstrein; Linda Moskovszky; Hans Martin Gissler; Tilmann Möltgen; Maciej Kwiatkowski; Stephen Wyler; Matthias Walter Journal: J Int Med Res Date: 2018-12-05 Impact factor: 1.671
Authors: Mike Wenzel; Luigi Nocera; Claudia Collà Ruvolo; Christoph Würnschimmel; Zhe Tian; Shahrokh F Shariat; Fred Saad; Alberto Briganti; Derya Tilki; Philipp Mandel; Andreas Becker; Luis A Kluth; Felix K H Chun; Pierre I Karakiewicz Journal: Cancer Causes Control Date: 2021-03-22 Impact factor: 2.506
Authors: Simone de Brot; Brian D Robinson; Tim Scase; Llorenç Grau-Roma; Eleanor Wilkinson; Stephen A Boorjian; David Gardner; Nigel P Mongan Journal: Oncol Lett Date: 2018-05-30 Impact factor: 2.967