Literature DB >> 27720637

Intraspinal stem cell transplantation for amyotrophic lateral sclerosis: Ready for efficacy clinical trials?

Nazem Atassi1, Ettore Beghi2, Miguel Blanquer3, Nicholas M Boulis4, Roberto Cantello5, Claudia Caponnetto6, Adriano Chiò7, Stephen B Dunnett8, Eva L Feldman9, Angelo Vescovi10, Letizia Mazzini11.   

Abstract

Intraspinal stem cell (SC) transplantation represents a new therapeutic approach for amyotrophic lateral sclerosis (ALS) clinical trials. There are considerable difficulties in designing future efficacy trials, some related to the field of ALS and some that are specific to SCs or the mode of delivery. In October 2015, the most controversial points on SC transplantation were addressed during an international workshop intended to bring together international SC and ALS researchers in a public discussion on a topic for which expertise is limited. During the meeting, a discussion was started on the basic structure of the ideal clinical trial testing the efficacy and safety of SC transplantation. The current document includes a number of consensus points reflecting the design of phase II/III clinical trials.
Copyright © 2016 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  ALS; clinical trials; stem cells; transplantation

Mesh：

Year:  2016        PMID： 27720637     DOI： 10.1016/j.jcyt.2016.08.005

Source DB:  PubMed          Journal:  Cytotherapy        ISSN： 1465-3249            Impact factor:   5.414


  6 in total

Review 1.  Pharmacotherapy for Amyotrophic Lateral Sclerosis: A Review of Approved and Upcoming Agents.

Authors:  Stephen A Johnson; Ton Fang; Fabiola De Marchi; Dylan Neel; Donatienne Van Weehaeghe; James D Berry; Sabrina Paganoni
Journal:  Drugs       Date:  2022-09-19       Impact factor: 11.431

Review 2.  Current view and perspectives in amyotrophic lateral sclerosis.

Authors:  Stéphane Mathis; Philippe Couratier; Adrien Julian; Philippe Corcia; Gwendal Le Masson
Journal:  Neural Regen Res       Date:  2017-02       Impact factor: 5.135

3.  Intraspinal Transplantation of the Adipose Tissue-Derived Regenerative Cells in Amyotrophic Lateral Sclerosis in Accordance with the Current Experts' Recommendations: Choosing Optimal Monitoring Tools.

Authors:  Magdalena Kuzma-Kozakiewicz; Andrzej Marchel; Anna Kaminska; Malgorzata Gawel; Jan Sznajder; Anna Figiel-Dabrowska; Arkadiusz Nowak; Edyta Maj; Natalia Ewa Krzesniak; Bartlomiej H Noszczyk; Krystyna Domanska-Janik; Anna Sarnowska
Journal:  Stem Cells Int       Date:  2018-08-12       Impact factor: 5.443

Review 4.  Maximizing the Survival of Amyotrophic Lateral Sclerosis Patients: Current Perspectives.

Authors:  Osama A Khairoalsindi; Ahmad R Abuzinadah
Journal:  Neurol Res Int       Date:  2018-08-12

5.  Results from Phase I Clinical Trial with Intraspinal Injection of Neural Stem Cells in Amyotrophic Lateral Sclerosis: A Long-Term Outcome.

Authors:  Letizia Mazzini; Maurizio Gelati; Daniela Celeste Profico; Gianni Sorarù; Daniela Ferrari; Massimiliano Copetti; Gianmarco Muzi; Claudia Ricciolini; Sandro Carletti; Cesare Giorgi; Cristina Spera; Domenico Frondizi; Stefano Masiero; Alessandro Stecco; Carlo Cisari; Enrica Bersano; Fabiola De Marchi; Maria Francesca Sarnelli; Giorgia Querin; Roberto Cantello; Francesco Petruzzelli; Annamaria Maglione; Cristina Zalfa; Elena Binda; Alberto Visioli; Domenico Trombetta; Barbara Torres; Laura Bernardini; Alessandra Gaiani; Maurilio Massara; Silvia Paolucci; Nicholas M Boulis; Angelo L Vescovi
Journal:  Stem Cells Transl Med       Date:  2019-05-18       Impact factor: 6.940

Review 6.  Motor neuron replacement therapy for amyotrophic lateral sclerosis.

Authors:  Bochao Liu; Mo Li; Lingyan Zhang; Zhiguo Chen; Paul Lu
Journal:  Neural Regen Res       Date:  2022-08       Impact factor: 5.135
  6 in total

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