Sune Dandanell1, Camilla Skovborg2, Charlotte Boslev Præst3, Kasper Bøgh Kristensen2, Malene Glerup Nielsen3, Sofie Lionett2, Sofie Drevsholt Jørgensen2, Andreas Vigelsø2, Flemming Dela4, Jørn Wulff Helge2. 1. Center for Healthy Aging, Department of Biomedical Sciences, XLab, University of Copenhagen, Denmark; Department for Physiotherapy and Occupational Therapy, Metropolitan University College, Copenhagen, Denmark. Electronic address: sunedj@sund.ku.dk. 2. Center for Healthy Aging, Department of Biomedical Sciences, XLab, University of Copenhagen, Denmark. 3. Center for Healthy Aging, Department of Biomedical Sciences, XLab, University of Copenhagen, Denmark; Department for Physiotherapy and Occupational Therapy, Metropolitan University College, Copenhagen, Denmark. 4. Center for Healthy Aging, Department of Biomedical Sciences, XLab, University of Copenhagen, Denmark; Geriatrics, Bispebjerg University Hospital, Copenhagen, Denmark.
Abstract
OBJECTIVE: Intensive lifestyle interventions (ILI) are criticised for ineffective obesity treatment because weight loss over time is modest and thus of limited clinical relevance. However, a subgroup (5-30%) maintains a clinical weight loss >10%, but it is not clear if cardiometabolic health follows this pattern. The aim was to study the effect of different magnitudes of weight loss maintenance after ILI on cardiometabolic health. METHODS: Eighty out of 2420 former participants (age: 36±1, BMI: 38±1, (means ±SE)) in an 11-12-week ILI were recruited into 3 groups; clinical weight loss maintenance (>10% weight loss), moderate maintenance (1-10%), and weight regain based on weight loss at follow-up (5.3±0.4years). Weight loss during the ILI was achieved by increased physical activity and hypo-caloric diet. Dual X-ray Absorptiometry, blood sample, skeletal muscle biopsy and VO2max test were used to determine cardiometabolic health at follow-up. RESULTS: At follow-up, the clinical weight loss maintenance group scored better in the following variables compared to the other groups: BMI (31±1, 33±2, 43±2kg/m2), composition (34±2, 40±1, 49±1% fat), visceral adipose tissue (0.8±0.2, 1.7±0.5, 2.4±0.4kg), plasma triglycerides (0.8±0.2, 1.3±0.4, 1.6±0.3mmol/L), plasma glucose (4.9±0.1, 5.9±0.4, 5.9±0.1mmol/L), Hb1Ac (5.1±0.0, 5.6±0.2, 5.8±0.2%), protein content in skeletal muscle of GLUT4 (1.5±0.2, 0.9±0.1, 1.0±0.1 AU) and hexokinase II (1.6±0.2, 1.0±0.2, 0.7±0.1 AU), citrate synthase activity (155±6, 130±5, 113±5μmol/g/min) and VO2max (49±1, 43±1, 41±1mL/min/FFM) (p<0.05). CONCLUSION: Cardiometabolic health is better in participants who have maintained >10% weight loss compared to moderate weight loss and weight regain.
OBJECTIVE: Intensive lifestyle interventions (ILI) are criticised for ineffective obesity treatment because weight loss over time is modest and thus of limited clinical relevance. However, a subgroup (5-30%) maintains a clinical weight loss >10%, but it is not clear if cardiometabolic health follows this pattern. The aim was to study the effect of different magnitudes of weight loss maintenance after ILI on cardiometabolic health. METHODS: Eighty out of 2420 former participants (age: 36±1, BMI: 38±1, (means ±SE)) in an 11-12-week ILI were recruited into 3 groups; clinical weight loss maintenance (>10% weight loss), moderate maintenance (1-10%), and weight regain based on weight loss at follow-up (5.3±0.4years). Weight loss during the ILI was achieved by increased physical activity and hypo-caloric diet. Dual X-ray Absorptiometry, blood sample, skeletal muscle biopsy and VO2max test were used to determine cardiometabolic health at follow-up. RESULTS: At follow-up, the clinical weight loss maintenance group scored better in the following variables compared to the other groups: BMI (31±1, 33±2, 43±2kg/m2), composition (34±2, 40±1, 49±1% fat), visceral adipose tissue (0.8±0.2, 1.7±0.5, 2.4±0.4kg), plasma triglycerides (0.8±0.2, 1.3±0.4, 1.6±0.3mmol/L), plasma glucose (4.9±0.1, 5.9±0.4, 5.9±0.1mmol/L), Hb1Ac (5.1±0.0, 5.6±0.2, 5.8±0.2%), protein content in skeletal muscle of GLUT4 (1.5±0.2, 0.9±0.1, 1.0±0.1 AU) and hexokinase II (1.6±0.2, 1.0±0.2, 0.7±0.1 AU), citrate synthase activity (155±6, 130±5, 113±5μmol/g/min) and VO2max (49±1, 43±1, 41±1mL/min/FFM) (p<0.05). CONCLUSION: Cardiometabolic health is better in participants who have maintained >10% weight loss compared to moderate weight loss and weight regain.
Authors: Sydney G O'Connor; Patrick Boyd; Caitlin P Bailey; Marissa M Shams-White; Tanya Agurs-Collins; Kara Hall; Jill Reedy; Edward R Sauter; Susan M Czajkowski Journal: Adv Nutr Date: 2021-03-31 Impact factor: 8.701
Authors: André C Carpentier; Denis P Blondin; Kirsi A Virtanen; Denis Richard; François Haman; Éric E Turcotte Journal: Front Endocrinol (Lausanne) Date: 2018-08-07 Impact factor: 5.555