Literature DB >> 2771958

5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous system.

S M Molineaux1, T M Jessell, R Axel, D Julius.   

Abstract

Neurons in rat central nervous system (CNS) that express 5-HT1c receptor mRNA have been localized by in situ hybridization histochemistry. The 5-HT1c receptor is expressed in a wide variety of cortical and subcortical neurons including hippocampal pyramidal neurons, neurons within most of the central monoaminergic cell groups, neurons in thalamic sensory relay nuclei, and neurons involved in the central processing and regulation of nociceptive transmission. Therefore, the 5-HT1c receptor is a prominent but poorly characterized central subclass of serotonin (5-HT) receptor. The distribution of the 5-HT1c receptor within the CNS is considerably more widespread than that of the structurally and functionally related 5-HT2 receptor.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2771958      PMCID： PMC297932          DOI： 10.1073/pnas.86.17.6793

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  26 in total

1.  A family of receptors coupled to guanine nucleotide regulatory proteins.

Authors:  H G Dohlman; M G Caron; R J Lefkowitz
Journal:  Biochemistry       Date:  1987-05-19       Impact factor: 3.162

2.  Microinjection of morphine into the periaqueductal gray evokes the release of serotonin from spinal cord.

Authors:  T L Yaksh; G M Tyce
Journal:  Brain Res       Date:  1979-07-27       Impact factor: 3.252

3.  An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat.

Authors:  E C Azmitia; M Segal
Journal:  J Comp Neurol       Date:  1978-06-01       Impact factor: 3.215

Review 4.  5-Hydroxytryptamine receptor subtypes.

Authors:  S J Peroutka
Journal:  Annu Rev Neurosci       Date:  1988       Impact factor: 12.449

5.  Central catecholamine neuron systems: anatomy and physiology of the dopamine systems.

Authors:  R Y Moore; F E Bloom
Journal:  Annu Rev Neurosci       Date:  1978       Impact factor: 12.449

6.  Cholinergic terminals in rat hippocampus possess 5-HT1B receptors mediating inhibition of acetylcholine release.

Authors:  G Maura; M Raiteri
Journal:  Eur J Pharmacol       Date:  1986-10-07       Impact factor: 4.432

7.  Multiple serotonin receptors: differential binding of [3H]5-hydroxytryptamine, [3H]lysergic acid diethylamide and [3H]spiroperidol.

Authors:  S J Peroutka; S H Snyder
Journal:  Mol Pharmacol       Date:  1979-11       Impact factor: 4.436

8.  Regulation of pro-opiomelanocortin gene transcription in individual cell nuclei.

Authors:  R T Fremeau; J R Lundblad; D B Pritchett; J N Wilcox; J L Roberts
Journal:  Science       Date:  1986-12-05       Impact factor: 47.728

9.  A G protein couples serotonin and GABAB receptors to the same channels in hippocampus.

Authors:  R Andrade; R C Malenka; R A Nicoll
Journal:  Science       Date:  1986-12-05       Impact factor: 47.728

10.  Contributions of cingulate cortex to two forms of spatial learning and memory.

Authors:  R J Sutherland; I Q Whishaw; B Kolb
Journal:  J Neurosci       Date:  1988-06       Impact factor: 6.167
View more
  59 in total

1.  DOI-Induced activation of the cortex: dependence on 5-HT2A heteroceptors on thalamocortical glutamatergic neurons.

Authors:  J L Scruggs; S Patel; M Bubser; A Y Deutch
Journal:  J Neurosci       Date:  2000-12-01       Impact factor: 6.167

2.  The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2.

Authors:  D S Barritt; M T Pearn; A H Zisch; S S Lee; R T Javier; E B Pasquale; W B Stallcup
Journal:  J Cell Biochem       Date:  2000-08-02       Impact factor: 4.429

3.  Serotonergic modulation of supragranular neurons in rat sensorimotor cortex.

Authors:  R C Foehring; J F M van Brederode; G A Kinney; W J Spain
Journal:  J Neurosci       Date:  2002-09-15       Impact factor: 6.167

4.  Serotonin 5-HT2C receptor protein expression is enriched in synaptosomal and post-synaptic compartments of rat cortex.

Authors:  Noelle C Anastasio; Maria Fe Lanfranco; Marcy J Bubar; Patricia K Seitz; Sonja J Stutz; Andrew G McGinnis; Cheryl S Watson; Kathryn A Cunningham
Journal:  J Neurochem       Date:  2010-03-24       Impact factor: 5.372

Review 5.  A short history of the 5-HT2C receptor: from the choroid plexus to depression, obesity and addiction treatment.

Authors:  Jose M Palacios; Angel Pazos; Daniel Hoyer
Journal:  Psychopharmacology (Berl)       Date:  2017-03-07       Impact factor: 4.530

6.  PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors.

Authors:  Atheir I Abbas; Prem N Yadav; Wei-Dong Yao; Margaret I Arbuckle; Seth G N Grant; Marc G Caron; Bryan L Roth
Journal:  J Neurosci       Date:  2009-06-03       Impact factor: 6.167

7.  The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors.

Authors:  D Julius; K N Huang; T J Livelli; R Axel; T M Jessell
Journal:  Proc Natl Acad Sci U S A       Date:  1990-02       Impact factor: 11.205

8.  A serotonin and melanocortin circuit mediates D-fenfluramine anorexia.

Authors:  Yong Xu; Juli E Jones; Danielle A Lauzon; Jason G Anderson; Nina Balthasar; Lora K Heisler; Andrew R Zinn; Bradford B Lowell; Joel K Elmquist
Journal:  J Neurosci       Date:  2010-11-03       Impact factor: 6.167

9.  Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy.

Authors:  B Schaerlinger; P Hickel; N Etienne; L Guesnier; L Maroteaux
Journal:  Br J Pharmacol       Date:  2003-08-11       Impact factor: 8.739

10.  Synthesis and Evaluation of Pyridyloxypyridyl Indole Carboxamides as Potential PET Imaging Agents for 5-HT2C Receptors.

Authors:  Fanxing Zeng; Jonathon A Nye; Ronald J Voll; Leonard Howell; Mark M Goodman
Journal:  ACS Med Chem Lett       Date:  2018-02-05       Impact factor: 4.345
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.