Laura Krogh Jørgensen1, Lars Skov Dalgaard2, Lars Jørgen Østergaard3, Mette Nørgaard4, Trine Hyrup Mogensen5. 1. Department of Infectious Diseases, Aarhus University Hospital, Palle Juul-Jensen Boulevard 99, 8200 Aarhus N, Denmark. Electronic address: laujoerg@rm.dk. 2. Department of Infectious Diseases, Aarhus University Hospital, Palle Juul-Jensen Boulevard 99, 8200 Aarhus N, Denmark. Electronic address: Lars.Dalgaard@skejby.rm.dk. 3. Department of Infectious Diseases, Aarhus University Hospital, Palle Juul-Jensen Boulevard 99, 8200 Aarhus N, Denmark. Electronic address: larsoest@rm.dk. 4. Department of Clinical Epidemiology, Aarhus University Hospital, Oluf Palmes Allé 43-45, 8200 Aarhus N, Denmark. Electronic address: mn@clin.au.dk. 5. Department of Infectious Diseases, Aarhus University Hospital, Palle Juul-Jensen Boulevard 99, 8200 Aarhus N, Denmark; Department of Biomedicine, Aarhus University, Vennelyst Blvd. 4, 8000 Aarhus C, Denmark. Electronic address: trinmoge@rm.dk.
Abstract
OBJECTIVES: We aimed to investigate the incidence and mortality of herpes simplex encephalitis (HSE) in a nationwide cohort. METHODS: From the Danish National Patient Registry, we identified all adults hospitalised with a first-time diagnosis of HSE in Denmark during 2004-2014. The HSE diagnoses were verified using medical records and microbiological data. Patients were followed for mortality through the Danish Civil Registry System. We estimated age-standardised incidence rates of HSE and 30-day, 60-day, and 1-year cumulative mortality. Furthermore, we assessed whether calendar year, age, gender, level of comorbidity, virus type, and department type was associated with HSE mortality. RESULTS: We identified a total of 230 cases of HSE. Median age was 60.7 years (interquartile range: 49.3-71.6). The overall incidence rate was 4.64 cases per million population per year (95% confidence interval: 4.06-5.28). The cumulative mortality within 30 days, 60 days, and 1 year of the HSE admission was 8.3%, 11.3%, and 18.6%, respectively. Advanced age and presence of comorbidity were associated with increased 60-day and 1-year mortality. CONCLUSIONS: This nationwide study of verified HSE found a higher incidence than reported in previous nationwide studies. Presence of comorbidity was identified as a novel adverse prognostic factor. Mortality rates following HSE remain high.
OBJECTIVES: We aimed to investigate the incidence and mortality of herpes simplex encephalitis (HSE) in a nationwide cohort. METHODS: From the Danish National Patient Registry, we identified all adults hospitalised with a first-time diagnosis of HSE in Denmark during 2004-2014. The HSE diagnoses were verified using medical records and microbiological data. Patients were followed for mortality through the Danish Civil Registry System. We estimated age-standardised incidence rates of HSE and 30-day, 60-day, and 1-year cumulative mortality. Furthermore, we assessed whether calendar year, age, gender, level of comorbidity, virus type, and department type was associated with HSE mortality. RESULTS: We identified a total of 230 cases of HSE. Median age was 60.7 years (interquartile range: 49.3-71.6). The overall incidence rate was 4.64 cases per million population per year (95% confidence interval: 4.06-5.28). The cumulative mortality within 30 days, 60 days, and 1 year of the HSE admission was 8.3%, 11.3%, and 18.6%, respectively. Advanced age and presence of comorbidity were associated with increased 60-day and 1-year mortality. CONCLUSIONS: This nationwide study of verified HSE found a higher incidence than reported in previous nationwide studies. Presence of comorbidity was identified as a novel adverse prognostic factor. Mortality rates following HSE remain high.
Authors: Ann-Brit E Hansen; Hanne T Vestergaard; Ram B Dessau; Jacob Bodilsen; Nanna S Andersen; Lars H Omland; Claus B Christiansen; Svend Ellermann-Eriksen; Lene Nielsen; Thomas Benfield; Henrik T Sørensen; Christian Ø Andersen; Anne-Mette Lebech; Niels Obel Journal: Clin Epidemiol Date: 2020-07-16 Impact factor: 4.790
Authors: Tomasz H Benedyk; Julia Muenzner; Viv Connor; Yue Han; Katherine Brown; Kaveesha J Wijesinghe; Yunhui Zhuang; Susanna Colaco; Guido A Stoll; Owen S Tutt; Stanislava Svobodova; Dmitri I Svergun; Neil A Bryant; Janet E Deane; Andrew E Firth; Cy M Jeffries; Colin M Crump; Stephen C Graham Journal: PLoS Pathog Date: 2021-08-16 Impact factor: 6.823