J E Creeth1, S A Kelly2, C González-Cabezas3, R Karwal4, E A Martinez-Mier5, R J M Lynch6, M L Bosma7, D T Zero8. 1. GlaxoSmithKline Consumer Healthcare, St George's Avenue, Weybridge, Surrey, UK. Electronic address: jonathan.e.creeth@gsk.com. 2. Oral Health Research Institute, School of Dentistry, 415 Lansing Street, Indiana University, Indianapolis, USA. Electronic address: sakelly@iu.edu. 3. Oral Health Research Institute, School of Dentistry, 415 Lansing Street, Indiana University, Indianapolis, USA. Electronic address: carlosgc@umich.edu. 4. GlaxoSmithKline Consumer Healthcare, 5 Golf Course Road, Gurgaon, Haryana, India. Electronic address: ritu.y.karwal@gsk.com. 5. Oral Health Research Institute, School of Dentistry, 415 Lansing Street, Indiana University, Indianapolis, USA. Electronic address: esmartin@iu.edu. 6. GlaxoSmithKline Consumer Healthcare, St George's Avenue, Weybridge, Surrey, UK. Electronic address: richard.j.lynch@gsk.com. 7. GlaxoSmithKline Consumer Healthcare, St George's Avenue, Weybridge, Surrey, UK. Electronic address: marylynnbosma@gmail.com. 8. Oral Health Research Institute, School of Dentistry, 415 Lansing Street, Indiana University, Indianapolis, USA. Electronic address: dzero@iu.edu.
Abstract
OBJECTIVES: The influence of toothbrushing duration and dentifrice quantity on fluoride efficacy against dental caries is poorly understood. This study investigated effects of these two oral hygiene factors on enamel remineralisation (measured as surface microhardness recovery [SMHR]), enamel fluoride uptake (EFU), and net acid resistance (NAR) post-remineralisation in a randomized clinical study using an in situ caries model. METHODS: Subjects (n=63) wore their partial dentures holding partially demineralised human enamel specimens and brushed twice-daily for two weeks, following each of five regimens: brushing for 120 or 45s with 1.5g of 1150ppm F (as NaF) dentifrice; for 120 or 45s with 0.5g of this dentifrice; and for 120s with 1.5g of 250ppm F (NaF) dentifrice. RESULTS: Comparing brushing for 120s against brushing for 45s, SMHR and EFU increased by 20.0% and 26.9% respectively when 1.5g dentifrice was used; and by 22.8% and 19.9% respectively when 0.5g dentifrice was used. Comparing brushing with 1.5g against brushing with 0.5g dentifrice, SMHR and EFU increased by 35.3% and 51.3% respectively when brushing for 120s, and by 38.4% and 43.0% respectively when brushing for 45s. Increasing brushing duration and dentifrice quantity also increased the NAR value. The effects of these two oral hygiene factors on SMHR, EFU, and NAR were statistically significant (p<0.05 in all cases). CONCLUSION: Brushing duration and dentifrice quantity have the potential to influence the anti-caries effectiveness of fluoride dentifrices. Study NCT01563172 on ClinicalTrials.gov. CLINICAL SIGNIFICANCE: The effect of two key oral hygiene regimen factors - toothbrushing duration and dentifrice quantity - on fluoride's anticaries effectiveness is unclear. This 2-week home-use in situ remineralisation clinical study showed both these factors can influence fluoride bioactivity, and so can potentially affect fluoride's ability to protect against caries. Copyright Â
RCT Entities:
OBJECTIVES: The influence of toothbrushing duration and dentifrice quantity on fluoride efficacy against dental caries is poorly understood. This study investigated effects of these two oral hygiene factors on enamel remineralisation (measured as surface microhardness recovery [SMHR]), enamel fluoride uptake (EFU), and net acid resistance (NAR) post-remineralisation in a randomized clinical study using an in situ caries model. METHODS: Subjects (n=63) wore their partial dentures holding partially demineralised human enamel specimens and brushed twice-daily for two weeks, following each of five regimens: brushing for 120 or 45s with 1.5g of 1150ppm F (as NaF) dentifrice; for 120 or 45s with 0.5g of this dentifrice; and for 120s with 1.5g of 250ppm F (NaF) dentifrice. RESULTS: Comparing brushing for 120s against brushing for 45s, SMHR and EFU increased by 20.0% and 26.9% respectively when 1.5g dentifrice was used; and by 22.8% and 19.9% respectively when 0.5g dentifrice was used. Comparing brushing with 1.5g against brushing with 0.5g dentifrice, SMHR and EFU increased by 35.3% and 51.3% respectively when brushing for 120s, and by 38.4% and 43.0% respectively when brushing for 45s. Increasing brushing duration and dentifrice quantity also increased the NAR value. The effects of these two oral hygiene factors on SMHR, EFU, and NAR were statistically significant (p<0.05 in all cases). CONCLUSION: Brushing duration and dentifrice quantity have the potential to influence the anti-caries effectiveness of fluoride dentifrices. Study NCT01563172 on ClinicalTrials.gov. CLINICAL SIGNIFICANCE: The effect of two key oral hygiene regimen factors - toothbrushing duration and dentifrice quantity - on fluoride's anticaries effectiveness is unclear. This 2-week home-use in situ remineralisation clinical study showed both these factors can influence fluoride bioactivity, and so can potentially affect fluoride's ability to protect against caries. Copyright Â
Authors: James R Fernando; Glenn D Walker; Thomas Kwan-Soo Park; Peiyan Shen; Yi Yuan; Coralie Reynolds; Eric C Reynolds Journal: Sci Rep Date: 2022-06-14 Impact factor: 4.996
Authors: Jin Xiao; Anderson T Hara; Dongyeop Kim; Domenick T Zero; Hyun Koo; Geelsu Hwang Journal: Int J Oral Sci Date: 2017-04-28 Impact factor: 6.344