Simone Donati1, Simona Maria Caprani1, Francesco Semeraro2, Riccardo Vinciguerra1, Gianni Virgili3, Francesco Testa4, Francesca Simonelli4, Claudio Azzolini1. 1. a Department of Surgical and Morphological Sciences , University of Insurbia-Circolo Hospital , Varese , Italy. 2. b Eye Clinic, Department of Neurological and Vision Sciences , University of Brescia , Brescia , Italy. 3. c Eye Clinic, Department of Translational Surgery and Medicine , University of Florence , Florence , Italy. 4. d Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences , Second University of Naples , Naples , Italy.
Abstract
PURPOSE: To analyze functional and morphological findings after surgery for idiopathic epiretinal macular membrane (IEMM). MATERIALS AND METHODS: Twenty eyes of 20 patients affected by IEMM underwent 23-Gauge surgery. Morphological and functional examinations were assessed at baseline and at 30, 90, and 180 days after surgery. SD-OCT evaluated foveal morphology and thickness, photoreceptor inner/outer segment junction, and external limiting membrane. Functional assessment evaluated visual acuity, retinal sensitivity, and fixation patterns. Statistical analysis was performed with the Student's t test and Pearson correlation test. RESULTS: Mean central retinal thickness (CRT), visual acuity (VA), and retinal sensitivity (RS) at baseline were respectively 494.90 ± 38.73 µm, 0.55 ± 0.08 LogMAR, and 11.13±1.02; after surgery, at day 180, we observed a significant decrease in mean CRT to 326.90±32.68 µm, an increase in mean VA to 0.33 ± 0.05 LogMAR (p < 0.05), and in mean RS to 13.25 ± 0.73 dB (p < 0.05). A stable fixation increased from 40% of patients at baseline to 75% of patients at day 180 (p < 0.05). DISCUSSION: IEMM surgery results in continuous improvement in visual function, not only at month one but also beyond month six, due to the progressive reduction of residual intraretinal edema and recomposition of retinal layers.
PURPOSE: To analyze functional and morphological findings after surgery for idiopathic epiretinal macular membrane (IEMM). MATERIALS AND METHODS: Twenty eyes of 20 patients affected by IEMM underwent 23-Gauge surgery. Morphological and functional examinations were assessed at baseline and at 30, 90, and 180 days after surgery. SD-OCT evaluated foveal morphology and thickness, photoreceptor inner/outer segment junction, and external limiting membrane. Functional assessment evaluated visual acuity, retinal sensitivity, and fixation patterns. Statistical analysis was performed with the Student's t test and Pearson correlation test. RESULTS: Mean central retinal thickness (CRT), visual acuity (VA), and retinal sensitivity (RS) at baseline were respectively 494.90 ± 38.73 µm, 0.55 ± 0.08 LogMAR, and 11.13±1.02; after surgery, at day 180, we observed a significant decrease in mean CRT to 326.90±32.68 µm, an increase in mean VA to 0.33 ± 0.05 LogMAR (p < 0.05), and in mean RS to 13.25 ± 0.73 dB (p < 0.05). A stable fixation increased from 40% of patients at baseline to 75% of patients at day 180 (p < 0.05). DISCUSSION: IEMM surgery results in continuous improvement in visual function, not only at month one but also beyond month six, due to the progressive reduction of residual intraretinal edema and recomposition of retinal layers.
Authors: Simone Donati; Carlo Gandolfi; Simona Maria Caprani; Jennifer Cattaneo; Laura Premoli; Claudio Azzolini Journal: Biomed Res Int Date: 2018-08-02 Impact factor: 3.411
Authors: Simone Donati; Paola Della Valle; Elias Premi; Marco Mazzola; Laura Lo Presti; Claudio Azzolini Journal: J Ophthalmol Date: 2019-04-14 Impact factor: 1.909