| Literature DB >> 27714586 |
Biljana Mihaljevic1,2, Jelena Jelicic3, Bosko Andjelic3,4, Darko Antic3,4, Olivera Markovic4,5, Ivan Petkovic6, Maja Perunicic Jovanovic7, Goran Trajkovic8, Jelena Bila3,4, Vladislava Djurasinovic3, Aleksandra Sretenovic3, Vojin Vukovic3, Mihailo Smiljanic3, Milena Todorovic Balint3,4.
Abstract
The Follicular Lymphoma International Prognostic Index (FLIPI) is widely used in the identification of risk groups among follicular lymphoma (FL) patients. The aim of the present study was to evaluate the prognostic value of FLIPI combined with the Charlson comorbidity index (CCI) and histological grade of lymphoma. 224 newly diagnosed FL patients (median age 56 years) treated with immunochemotherapy were retrospectively analysed. Low FLIPI had 21.0 % of patients, intermediate 28.1 % and high 46.9 %. 50.9 % of patients had no comorbidities. Only 7.1 % of patients had a high CCI score (≥2), while 25.9 % of patients were histological grade 3. Parameters that influenced overall survival were evaluated using Cox regression analysis, in which CCI, FLIPI and histological grade (p < 0.05) retained prognostic significance. By combining these parameters, we have developed the FCG score, which incorporates FLIPI, CCI, and histological grade. This score defines three risk categories (low: 41.5 %; intermediate: 37.5 %; high: 13.4 %), associated with significantly different survival (p < 0.0001); this consequently improves discriminative power by 9.1 % compared to FLIPI. FCG score represents a possible new prognostic index, highlighting the role of the patient's clinical state and the histological characteristics of disease, as indicated by comorbidity index and histological grade of lymphoma.Entities:
Keywords: Comorbidity index; FLIPI; Follicular lymphoma; Histological grade
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Year: 2016 PMID： 27714586 DOI： 10.1007/s12185-016-2099-7
Source DB: PubMed Journal: Int J Hematol ISSN： 0925-5710 Impact factor: 2.490