| Literature DB >> 27713092 |
Kenneth R Cooke1, Leo Luznik2, Stefanie Sarantopoulos3, Frances T Hakim4, Madan Jagasia5, Daniel H Fowler4, Marcel R M van den Brink6, John A Hansen7, Robertson Parkman8, David B Miklos9, Paul J Martin7, Sophie Paczesny10, Georgia Vogelsang2, Steven Pavletic4, Jerome Ritz11, Kirk R Schultz12, Bruce R Blazar13.
Abstract
Chronic graft-versus-host disease (GVHD) is the leading cause of late, nonrelapse mortality and disability in allogeneic hematopoietic cell transplantation recipients and a major obstacle to improving outcomes. The biology of chronic GVHD remains enigmatic, but understanding the underpinnings of the immunologic mechanisms responsible for the initiation and progression of disease is fundamental to developing effective prevention and treatment strategies. The goals of this task force review are as follows: This document is intended as a review of our understanding of chronic GVHD biology and therapies resulting from preclinical studies, and as a platform for developing innovative clinical strategies to prevent and treat chronic GVHD. Published by Elsevier Inc.Entities:
Keywords: Blood and marrow transplantation; Chronic graft-versus-host disease; Clinical manifestations; Immune mechanisms
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Year: 2016 PMID： 27713092 PMCID： PMC6020045 DOI： 10.1016/j.bbmt.2016.09.023
Source DB: PubMed Journal: Biol Blood Marrow Transplant ISSN： 1083-8791 Impact factor: 5.742