Literature DB >> 27711752

Anti-inflammatory activity and enhanced COX-2 selectivity of nitric oxide-donating zinc(ii)-NSAID complexes.

Triloke Ranjan Lakshman1, Jolly Deb1, Tapan Kanti Paine1.   

Abstract

Zinc(ii)-NSAID complexes supported by NO-donating 1,10-phenanthrolinefuroxan exhibit anti-inflammatory activities through selective inhibition of the COX-2 pathway. The strategy represents a general procedure to convert non-selective or COX-1 selective NSAIDs to selective COX-2 inhibitors.

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Year:  2016        PMID: 27711752     DOI: 10.1039/c6dt00838k

Source DB:  PubMed          Journal:  Dalton Trans        ISSN: 1477-9226            Impact factor:   4.390


  1 in total

1.  Polypyridyl Zinc(II)-Indomethacin Complexes with Potent Anti-Breast Cancer Stem Cell Activity.

Authors:  Tiffany K Rundstadler; Arvin Eskandari; Sarah M Norman; Kogularamanan Suntharalingam
Journal:  Molecules       Date:  2018-09-04       Impact factor: 4.411

  1 in total

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