Literature DB >> 2771164

Low glutathione levels in brain regions of aged rats.

V Ravindranath1, B R Shivakumar, H K Anandatheerthavarada.   

Abstract

Glutathione (GSH) was measured in 6 regions of brain and liver of young adult, middle-aged and aged rats. GSH levels were significantly lower in cortex, cerebellum, striatum, thalamus and hippocampus of aged rats, while no changes were observed in liver as compared to young adult rats. On the other hand, lipid peroxidation as measured by thiobarbituric acid-reactive products increased significantly in all the regions of brain examined and in the liver of aged rats. Since GSH plays an important role as a cellular protectant against oxygen radical-mediated injury, decreased levels of GSH in aged rat brain are indicative of the vulnerability of the aged cerebral tissue to oxidative injury.

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Year:  1989        PMID： 2771164     DOI： 10.1016/0304-3940(89)90528-4

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  16 in total

1.  Doubly selective multiple quantum chemical shift imaging and T(1) relaxation time measurement of glutathione (GSH) in the human brain in vivo.

Authors:  In-Young Choi; Phil Lee
Journal:  NMR Biomed       Date:  2012-06-22       Impact factor: 4.044

Review 2.  Cysteine Metabolism in Neuronal Redox Homeostasis.

Authors:  Bindu D Paul; Juan I Sbodio; Solomon H Snyder
Journal:  Trends Pharmacol Sci       Date:  2018-03-09       Impact factor: 14.819

3.  Bcl-2 is a novel interacting partner for the 2-oxoglutarate carrier and a key regulator of mitochondrial glutathione.

Authors:  Heather M Wilkins; Kristin Marquardt; Lawrence H Lash; Daniel A Linseman
Journal:  Free Radic Biol Med       Date:  2011-11-09       Impact factor: 7.376

4.  Oxidative stress interferes with white matter renewal after prolonged cerebral hypoperfusion in mice.

Authors:  Nobukazu Miyamoto; Takakuni Maki; Loc-Duyen D Pham; Kazuhide Hayakawa; Ji Hae Seo; Emiri T Mandeville; Joseph B Mandeville; Kyu-Won Kim; Eng H Lo; Ken Arai
Journal:  Stroke       Date:  2013-09-26       Impact factor: 7.914

5.  Mitochondrial glutathione transport is a key determinant of neuronal susceptibility to oxidative and nitrosative stress.

Authors:  Heather M Wilkins; Danielle Kirchhof; Evan Manning; Jamie W Joseph; Daniel A Linseman
Journal:  J Biol Chem       Date:  2013-01-02       Impact factor: 5.157

6.  A radical scavenger edaravone inhibits matrix metalloproteinase-9 upregulation and blood-brain barrier breakdown in a mouse model of prolonged cerebral hypoperfusion.

Authors:  Nobukazu Miyamoto; Loc-Duyen D Pham; Takakuni Maki; Anna C Liang; Ken Arai
Journal:  Neurosci Lett       Date:  2014-05-10       Impact factor: 3.046

7.  Glutathione and gamma-glutamyl transpeptidase are differentially distributed in the olfactory mucosa of rats.

Authors:  N S Krishna; M L Getchell; S S Tate; F L Margolis; T V Getchell
Journal:  Cell Tissue Res       Date:  1992-12       Impact factor: 5.249

Review 8.  Redox Mechanisms in Neurodegeneration: From Disease Outcomes to Therapeutic Opportunities.

Authors:  Juan I Sbodio; Solomon H Snyder; Bindu D Paul
Journal:  Antioxid Redox Signal       Date:  2018-05-04       Impact factor: 8.401

9.  Protective effects of edaravone on white matter pathology in a novel mouse model of Alzheimer's disease with chronic cerebral hypoperfusion.

Authors:  Tian Feng; Toru Yamashita; Ryo Sasaki; Koh Tadokoro; Namiko Matsumoto; Nozomi Hishikawa; Koji Abe
Journal:  J Cereb Blood Flow Metab       Date:  2020-10-26       Impact factor: 6.200

10.  Beta-amyloidolysis and glutathione in Alzheimer's disease.

Authors:  J Lasierra-Cirujeda; P Coronel; Mj Aza; M Gimeno
Journal:  J Blood Med       Date:  2013-04-15
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