BACKGROUND: The receptor for advanced glycation end-products (RAGE) is a multiligand transmembrane receptor that is overexpressed in various pathological conditions including cancers. However, the expression pattern of RAGE in breast cancer tumors is still not completely clear. METHODS: In this study, we investigated the expression levels of RAGE in 25 fresh-frozen breast cancer samples and corresponding noncancerous tissue samples collected from breast cancer patients, by real-time polymerase chain reaction (PCR). Additionally, we performed immunohistochemistry on breast cancer specimens. RESULTS: The results indicate a high expression of the RAGE-encoding gene in the cancerous tissues. RAGE expression at the mRNA and protein levels was statistically significantly up-regulated in advanced-stage and triple-negative breast tumors and node-positive tissues compared with other tissues (p < 0.001). A significant association between RAGE expression and tumor size was observed (p = 0.029). CONCLUSIONS: Overexpression of RAGE in advanced-stage tumors may be a useful biomarker for diagnosis and the prediction of breast cancer progression.
BACKGROUND: The receptor for advanced glycation end-products (RAGE) is a multiligand transmembrane receptor that is overexpressed in various pathological conditions including cancers. However, the expression pattern of RAGE in breast cancer tumors is still not completely clear. METHODS: In this study, we investigated the expression levels of RAGE in 25 fresh-frozen breast cancer samples and corresponding noncancerous tissue samples collected from breast cancerpatients, by real-time polymerase chain reaction (PCR). Additionally, we performed immunohistochemistry on breast cancer specimens. RESULTS: The results indicate a high expression of the RAGE-encoding gene in the cancerous tissues. RAGE expression at the mRNA and protein levels was statistically significantly up-regulated in advanced-stage and triple-negative breast tumors and node-positive tissues compared with other tissues (p < 0.001). A significant association between RAGE expression and tumor size was observed (p = 0.029). CONCLUSIONS: Overexpression of RAGE in advanced-stage tumors may be a useful biomarker for diagnosis and the prediction of breast cancer progression.
Authors: Lindsay L Peterson; Seho Park; Yikyung Park; Graham A Colditz; Narges Anbardar; David P Turner Journal: Cancer Date: 2020-02-25 Impact factor: 6.860
Authors: Omonefe O Omofuma; David P Turner; Lindsay L Peterson; Anwar T Merchant; Jiajia Zhang; Susan E Steck Journal: Cancer Prev Res (Phila) Date: 2020-03-13
Authors: Omonefe O Omofuma; Lindsay L Peterson; David P Turner; Anwar T Merchant; Jiajia Zhang; Cynthia A Thomson; Marian L Neuhouser; Linda G Snetselaar; Bette J Caan; Aladdin H Shadyab; Nazmus Saquib; Hailey R Banack; Jaime Uribarri; Susan E Steck Journal: Cancer Epidemiol Biomarkers Prev Date: 2021-09-28 Impact factor: 4.090