Literature DB >> 27710785

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.

Peng Yuan, Carlo Condello, C Dirk Keene, Yaming Wang, Thomas D Bird, Steven M Paul, Wenjie Luo, Marco Colonna, David Baddeley, Jaime Grutzendler.   

Abstract

Entities:  

Year:  2016        PMID: 27710785     DOI: 10.1016/j.neuron.2016.09.016

Source DB:  PubMed          Journal:  Neuron        ISSN: 0896-6273            Impact factor:   17.173


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  69 in total

Review 1.  Environmental and Dietary Exposure to Copper and Its Cellular Mechanisms Linking to Alzheimer's Disease.

Authors:  Heng-Wei Hsu; Stephen C Bondy; Masashi Kitazawa
Journal:  Toxicol Sci       Date:  2018-06-01       Impact factor: 4.849

Review 2.  Triggering receptor expressed on myeloid cells 2 (TREM2): a potential therapeutic target for Alzheimer disease?

Authors:  Yuetiva Deming; Zeran Li; Bruno A Benitez; Carlos Cruchaga
Journal:  Expert Opin Ther Targets       Date:  2018-06-20       Impact factor: 6.902

3.  Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer's disease patient brain samples.

Authors:  Stefan Prokop; Kelly R Miller; Sergio R Labra; Rose M Pitkin; Kevt'her Hoxha; Sneha Narasimhan; Lakshmi Changolkar; Alyssa Rosenbloom; Virginia M-Y Lee; John Q Trojanowski
Journal:  Acta Neuropathol       Date:  2019-07-26       Impact factor: 17.088

Review 4.  Apolipoprotein E and Alzheimer's disease: the influence of apolipoprotein E on amyloid-β and other amyloidogenic proteins.

Authors:  Tien-Phat V Huynh; Albert A Davis; Jason D Ulrich; David M Holtzman
Journal:  J Lipid Res       Date:  2017-02-27       Impact factor: 5.922

5.  TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant Trem2R47H on murine myeloid cell function.

Authors:  Qingwen Cheng; Jean Danao; Santosh Talreja; Paul Wen; Jun Yin; Ning Sun; Chi-Ming Li; Danny Chui; David Tran; Samir Koirala; Hang Chen; Ian N Foltz; Songli Wang; Shilpa Sambashivan
Journal:  J Biol Chem       Date:  2018-03-29       Impact factor: 5.157

6.  The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk.

Authors:  Yuetiva Deming; Fabia Filipello; Francesca Cignarella; Claudia Cantoni; Simon Hsu; Robert Mikesell; Zeran Li; Jorge L Del-Aguila; Umber Dube; Fabiana Geraldo Farias; Joseph Bradley; John Budde; Laura Ibanez; Maria Victoria Fernandez; Kaj Blennow; Henrik Zetterberg; Amanda Heslegrave; Per M Johansson; Johan Svensson; Bengt Nellgård; Alberto Lleo; Daniel Alcolea; Jordi Clarimon; Lorena Rami; José Luis Molinuevo; Marc Suárez-Calvet; Estrella Morenas-Rodríguez; Gernot Kleinberger; Michael Ewers; Oscar Harari; Christian Haass; Thomas J Brett; Bruno A Benitez; Celeste M Karch; Laura Piccio; Carlos Cruchaga
Journal:  Sci Transl Med       Date:  2019-08-14       Impact factor: 17.956

7.  The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.

Authors:  Susanne Krasemann; Charlotte Madore; Ron Cialic; Caroline Baufeld; Narghes Calcagno; Rachid El Fatimy; Lien Beckers; Elaine O'Loughlin; Yang Xu; Zain Fanek; David J Greco; Scott T Smith; George Tweet; Zachary Humulock; Tobias Zrzavy; Patricia Conde-Sanroman; Mar Gacias; Zhiping Weng; Hao Chen; Emily Tjon; Fargol Mazaheri; Kristin Hartmann; Asaf Madi; Jason D Ulrich; Markus Glatzel; Anna Worthmann; Joerg Heeren; Bogdan Budnik; Cynthia Lemere; Tsuneya Ikezu; Frank L Heppner; Vladimir Litvak; David M Holtzman; Hans Lassmann; Howard L Weiner; Jordi Ochando; Christian Haass; Oleg Butovsky
Journal:  Immunity       Date:  2017-09-19       Impact factor: 31.745

Review 8.  Leveraging preclinical models for the development of Alzheimer disease therapeutics.

Authors:  Kimberly Scearce-Levie; Pascal E Sanchez; Joseph W Lewcock
Journal:  Nat Rev Drug Discov       Date:  2020-04-08       Impact factor: 84.694

9.  Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo.

Authors:  Jonathan Hasselmann; Morgan A Coburn; Whitney England; Dario X Figueroa Velez; Sepideh Kiani Shabestari; Christina H Tu; Amanda McQuade; Mahshad Kolahdouzan; Karla Echeverria; Christel Claes; Taylor Nakayama; Ricardo Azevedo; Nicole G Coufal; Claudia Z Han; Brian J Cummings; Hayk Davtyan; Christopher K Glass; Luke M Healy; Sunil P Gandhi; Robert C Spitale; Mathew Blurton-Jones
Journal:  Neuron       Date:  2019-07-30       Impact factor: 17.173

Review 10.  Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease.

Authors:  Tiantian Guo; Denghong Zhang; Yuzhe Zeng; Timothy Y Huang; Huaxi Xu; Yingjun Zhao
Journal:  Mol Neurodegener       Date:  2020-07-16       Impact factor: 14.195

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