Hack-Lyoung Kim1, Myung-A Kim1, Sohee Oh1, Mina Kim2, Seong Mi Park2, Hyun Ju Yoon3, Mi Seung Shin4, Kyung-Soon Hong5, Gil Ja Shin6, Wan-Joo Shim2. 1. 1 Seoul National University Boramae Medical Center , Seoul, Korea. 2. 2 Korea University Anam Hospital , Seoul, Korea. 3. 3 Chonnam National University Hospital , Gwangju, Korea. 4. 4 Gachon University Gil Medical Center , Incheon, Korea. 5. 5 Hanllym University Chuncheon Sacred Heart Hospital , Chuncheon, Korea. 6. 6 Ewha Womans University Mokdong Hospital , Seoul, Korea.
Abstract
BACKGROUND: Sex-related differences in the influence of metabolic syndrome (MetS) on various cardiovascular diseases have been suggested. The aim of this study was to investigate the effect of sex on the association between MetS and left ventricular (LV) diastolic dysfunction in patients with suspected coronary artery disease (CAD). METHODS: Two hundred ten patients (105 men and age-matched 105 women; mean age: 56.5 ± 10.9 years) undergoing elective coronary angiography for the evaluation of CAD were studied. MetS was defined according to the International Diabetes Federation criteria. LV diastolic function was assessed using transthoracic echocardiography. RESULTS: The incidence of MetS was 23.8% in men and 14.3% in women (P = 0.079). The incidence of LV diastolic dysfunction was significantly different by MetS in women, but not in men. In multiple linear regression analyses, the number of MetS components was independently associated with septal e' velocity, E/e', and left atrial (LA) diameter in women (P < 0.05 for each). In men, the number of MetS components was associated with only LA size in this analysis. As the number of components of MetS increased, septal e' velocity decreased proportionally in women (P < 0.001), but not in men (P = 0.117). CONCLUSIONS: Among middle-aged and elderly Korean patients at high risk of CAD, the impact of MetS on LV diastolic dysfunction was more pronounced in women than in men. This suggests the important role of sex hormonal effects in the development of LV diastolic dysfunction in relation to MetS in this population.
BACKGROUND: Sex-related differences in the influence of metabolic syndrome (MetS) on various cardiovascular diseases have been suggested. The aim of this study was to investigate the effect of sex on the association between MetS and left ventricular (LV) diastolic dysfunction in patients with suspected coronary artery disease (CAD). METHODS: Two hundred ten patients (105 men and age-matched 105 women; mean age: 56.5 ± 10.9 years) undergoing elective coronary angiography for the evaluation of CAD were studied. MetS was defined according to the International Diabetes Federation criteria. LV diastolic function was assessed using transthoracic echocardiography. RESULTS: The incidence of MetS was 23.8% in men and 14.3% in women (P = 0.079). The incidence of LV diastolic dysfunction was significantly different by MetS in women, but not in men. In multiple linear regression analyses, the number of MetS components was independently associated with septal e' velocity, E/e', and left atrial (LA) diameter in women (P < 0.05 for each). In men, the number of MetS components was associated with only LA size in this analysis. As the number of components of MetS increased, septal e' velocity decreased proportionally in women (P < 0.001), but not in men (P = 0.117). CONCLUSIONS: Among middle-aged and elderly Korean patients at high risk of CAD, the impact of MetS on LV diastolic dysfunction was more pronounced in women than in men. This suggests the important role of sex hormonal effects in the development of LV diastolic dysfunction in relation to MetS in this population.
Entities:
Keywords:
coronary artery disease; diastolic function; metabolic syndrome; sex
Authors: Milton Packer; Carolyn S P Lam; Lars H Lund; Mathew S Maurer; Barry A Borlaug Journal: Eur J Heart Fail Date: 2020-06-26 Impact factor: 15.534
Authors: Hyun-Jin Kim; Myung-A Kim; Hack-Lyoung Kim; Wan Joo Shim; Seong Mi Park; Mina Kim; Hyun Ju Yoon; Mi Seung Shin; Kyung-Soon Hong; Gil Ja Shin; Yong-Hyun Kim; Jin Oh Na; Jin-Ok Jeong Journal: BMJ Open Date: 2018-12-27 Impact factor: 2.692