McI Lier1, R F Malik1, Jhtm van Waesberghe2, J W Maas3, D A van Rumpt-van de Geest4, S F Coppus5, J P Berger6, B B van Rijn7,8, P F Janssen9, M A de Boer10, Jip de Vries10, F W Jansen11, I A Brosens12, C B Lambalk1, V Mijatovic1. 1. Department of Reproductive Medicine, VU University Medical Centre, Endometriosis Centre VUmc, Amsterdam, the Netherlands. 2. Department of Radiology, VU University Medical Centre, Endometriosis Centre VUmc, Amsterdam, the Netherlands. 3. Department of Obstetrics & Gynaecology, Maxima Medical Centre, Veldhoven, the Netherlands. 4. Department of Obstetrics & Gynaecology, Reinier de Graaf Gasthuis, Delft, the Netherlands. 5. Department of Obstetrics & Gynaecology, Radboud University Medical Centre, Nijmegen, the Netherlands. 6. Department of Obstetrics & Gynaecology, Bronovo Hospital, Den Haag, the Netherlands. 7. Department of Obstetrics, Wilhelmina Children's Hospital Birth Centre, University Medical Centre Utrecht, Utrecht, the Netherlands. 8. Academic Unit Human Development and Health, Institute for Life Sciences, University of Southampton, Southampton, UK. 9. Department of Obstetrics & Gynaecology, St. Elisabeth Hospital, Tilburg, the Netherlands. 10. Department of Obstetrics & Gynaecology, VU University Medical Centre, Amsterdam, the Netherlands. 11. Department of Obstetrics & Gynaecology, Leiden University Medical Centre, Leiden, the Netherlands. 12. Leuven Institute for Fertility and Embryology, Leuven, Belgium.
Abstract
OBJECTIVE: To report pregnancy outcomes of SHiP (spontaneous haemoperitoneum in pregnancy) and the association with endometriosis. DESIGN: Retrospective case note review. SETTING: Dutch referral hospitals for endometriosis. SAMPLE: Eleven women presenting with 15 events of SHiP. METHODS: In collaboration with the Dutch Working Group on Endometriosis, unpublished cases of SHiP that occurred in the Netherlands between 2010 and 2015 were retrieved. MAIN OUTCOME MEASURES: Maternal and perinatal mortality and morbidity. RESULTS: SHiP occurred predominantly in the second and third trimester of pregnancy. The earliest and major presenting symptom was an acute onset of abdominal pain, often combined with low haemoglobin levels or signs of fetal distress. Imaging was a diagnostic tool when free peritoneal fluid could be observed. For surgical treatment of the bleeding site, a midline laparotomy was mostly needed, the median estimated amount of blood loss was 2000 mL. No fetomaternal or perinatal mortality was reported, despite a high rate of preterm births (54.5%). In all women, endometriosis was diagnosed at a certain moment in time and therefore was probably involved in the pathogenesis of SHiP. Four women showed recurrence of SHiP. In one of these cases the second event of SHiP occurred in a subsequent pregnancy. CONCLUSION: Pregnancy outcomes of SHiP are improving when compared with previous reports, with absent fetomaternal and perinatal mortality in this recent series. Growing knowledge and adequate multidisciplinary intervention may have contributed to these favourable results. Increasing awareness of this serious complication of pregnancy is advocated, especially in women diagnosed with endometriosis. TWEETABLE ABSTRACT: Growing awareness of SHiP is advocated, especially in women diagnosed with endometriosis.
OBJECTIVE: To report pregnancy outcomes of SHiP (spontaneous haemoperitoneum in pregnancy) and the association with endometriosis. DESIGN: Retrospective case note review. SETTING: Dutch referral hospitals for endometriosis. SAMPLE: Eleven women presenting with 15 events of SHiP. METHODS: In collaboration with the Dutch Working Group on Endometriosis, unpublished cases of SHiP that occurred in the Netherlands between 2010 and 2015 were retrieved. MAIN OUTCOME MEASURES: Maternal and perinatal mortality and morbidity. RESULTS: SHiP occurred predominantly in the second and third trimester of pregnancy. The earliest and major presenting symptom was an acute onset of abdominal pain, often combined with low haemoglobin levels or signs of fetal distress. Imaging was a diagnostic tool when free peritoneal fluid could be observed. For surgical treatment of the bleeding site, a midline laparotomy was mostly needed, the median estimated amount of blood loss was 2000 mL. No fetomaternal or perinatal mortality was reported, despite a high rate of preterm births (54.5%). In all women, endometriosis was diagnosed at a certain moment in time and therefore was probably involved in the pathogenesis of SHiP. Four women showed recurrence of SHiP. In one of these cases the second event of SHiP occurred in a subsequent pregnancy. CONCLUSION: Pregnancy outcomes of SHiP are improving when compared with previous reports, with absent fetomaternal and perinatal mortality in this recent series. Growing knowledge and adequate multidisciplinary intervention may have contributed to these favourable results. Increasing awareness of this serious complication of pregnancy is advocated, especially in women diagnosed with endometriosis. TWEETABLE ABSTRACT: Growing awareness of SHiP is advocated, especially in women diagnosed with endometriosis.
Authors: Anne Elodie Millischer; Louis Marcellin; Pietro Santulli; Chloe Maignien; Mathilde Bourdon; Bruno Borghese; François Goffinet; Charles Chapron Journal: PLoS One Date: 2019-10-04 Impact factor: 3.240