Literature DB >> 27703158

Three structurally-related impurities in norvancomycin drug substance.

Zhibo Jiang1, Xuan Lei1, Minghua Chen1, Bingya Jiang1, Linzhuan Wu1, Xuexia Zhang2, Zhihui Zheng2, Xinxin Hu1, Xuefu You1, Shuyi Si1, Lifei Wang1, Bin Hong1.   

Abstract

Norvancomycin (NVCM) is widely used in China to treat bacterial infections of Gram-positive cocci and bacilli, especially infections of methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus epidermidis. This study is a chemical investigation of the drug substance of NVCM, and led to the identification, by 1D, 2D NMR spectra and HRESIMS, of three as yet undescribed impurities, one D-O-E ring expanded NVCM analog (1) and two derivatives of NVCM lacking sugars (2, 3).

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Year:  2016        PMID： 27703158     DOI： 10.1038/ja.2016.115

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  12 in total

Review 1.  Implications of vancomycin degradation products on therapeutic drug monitoring in patients with end-stage renal disease.

Authors:  A L Somerville; D H Wright; J C Rotschafer
Journal:  Pharmacotherapy       Date:  1999-06       Impact factor: 4.705

2.  Establishment of norvancomycin fluorescence polarization immunoassay for therapeutic drug monitoring.

Authors:  Xiao-Jie Wu; Jing Zhang; Ji-Cheng Yu; Guo-Ying Cao; Yao-Guo Shi; Ying-Yuan Zhang; Ming-Gui Wang
Journal:  J Antibiot (Tokyo)       Date:  2011-11-02       Impact factor: 2.649

3.  Development and validation of an HPLC method for vancomycin and its application to a pharmacokinetic study.

Authors:  María José de Jesús Valle; Francisco González López; Amparo Sánchez Navarro
Journal:  J Pharm Biomed Anal       Date:  2008-06-14       Impact factor: 3.935

4.  Quality assessment of U.S. marketplace vancomycin for injection products using high-resolution liquid chromatography-mass spectrometry and potency assays.

Authors:  Michael E Hadwiger; Cynthia D Sommers; Daniel J Mans; Vikram Patel; Michael T Boyne
Journal:  Antimicrob Agents Chemother       Date:  2012-02-27       Impact factor: 5.191

5.  Determination of vancomycin related substances by gradient high-performance liquid chromatography.

Authors:  E L Inman
Journal:  J Chromatogr       Date:  1987-12-11

Review 6.  Structure-activity relationships of vancomycin-type glycopeptide antibiotics.

Authors:  R Nagarajan
Journal:  J Antibiot (Tokyo)       Date:  1993-08       Impact factor: 2.649

7.  Investigation of vancomycin and related substances by liquid chromatography/ion trap mass spectrometry.

Authors:  J Diana; D Visky; J Hoogmartens; A Van Schepdael; E Adams
Journal:  Rapid Commun Mass Spectrom       Date:  2006       Impact factor: 2.419

8.  Development and validation of an improved method for the analysis of vancomycin by liquid chromatography selectivity of reversed-phase columns towards vancomycin components.

Authors:  José Diana; Dora Visky; Eugène Roets; Jos Hoogmartens
Journal:  J Chromatogr A       Date:  2003-05-09       Impact factor: 4.759

9.  Draft Genome Sequence of Norvancomycin-Producing Strain Amycolatopsis orientalis CPCC200066.

Authors:  Xuan Lei; Fang Yuan; Yuanyuan Shi; Xingxing Li; Lifei Wang; Bin Hong
Journal:  Genome Announc       Date:  2015-05-14

10.  Complete genome sequence and comparative genomic analyses of the vancomycin-producing Amycolatopsis orientalis.

Authors:  Li Xu; He Huang; Wei Wei; Yi Zhong; Biao Tang; Hua Yuan; Li Zhu; Weiyi Huang; Mei Ge; Shen Yang; Huajun Zheng; Weihong Jiang; Daijie Chen; Guo-Ping Zhao; Wei Zhao
Journal:  BMC Genomics       Date:  2014-05-13       Impact factor: 3.969
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  2 in total

1.  Comparative Assessment of Distribution Characteristics and Ocular Pharmacokinetics of Norvancomycin Between Continuous Topical Ocular Instillation and Hourly Administration of Eye Drop.

Authors:  Wenxiang Lin; Libei Zhao; Xuetao Huang; Qian Tan; Manqiang Peng; Muhammad Ahmad Khan; Ding Lin
Journal:  Drug Des Devel Ther       Date:  2020-02-26       Impact factor: 4.162

2.  Treatment of Severe Acute Bacterial Keratitis in Rabbits Using Continuous Topical Ocular Instillation with Norvancomycin.

Authors:  Wenxiang Lin; Libei Zhao; Qian Tan; Ding Lin
Journal:  Drug Des Devel Ther       Date:  2021-02-16       Impact factor: 4.162
  2 in total

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