Literature DB >> 27701869

Nanosizing a Metal-Organic Framework Enzyme Carrier for Accelerating Nerve Agent Hydrolysis.

Peng Li, Su-Young Moon, Mark A Guelta1, Lu Lin2, Diego A Gómez-Gualdrón, Randall Q Snurr, Steven P Harvey1, Joseph T Hupp, Omar K Farha3.   

Abstract

We report the synthesis and characterization of a water-stable zirconium metal-organic framework (MOF), NU-1003, featuring the largest mesoporous aperture known for a zirconium MOF. This material has been used to immobilize the nerve agent hydrolyzing enzyme, organophosphorus acid anhydrolase (OPAA). The catalytic efficiency of immobilized OPAA in nanosized NU-1003 is significantly increased compared to that of OPAA immobilized in microsized NU-1003 and even exceeds that of the free OPAA enzyme. This paper highlights a method for rapid and highly efficient hydrolysis of nerve agents using nanosized enzyme carriers.

Entities:  

Keywords:  enzyme immobilization; metal−organic framework; nanocarrier; nerve agent catalysis

Year:  2016        PMID： 27701869     DOI： 10.1021/acsnano.6b04996

Source DB:  PubMed          Journal:  ACS Nano        ISSN： 1936-0851            Impact factor:   15.881


  17 in total

1.  In situ polymerization on nanoscale metal-organic frameworks for enhanced physiological stability and stimulus-responsive intracellular drug delivery.

Authors:  Yuan Liu; Christina S Gong; Yunlu Dai; Zhen Yang; Guocan Yu; Yijing Liu; Mingru Zhang; Lisen Lin; Wei Tang; Zijian Zhou; Guizhi Zhu; Jiji Chen; Orit Jacobson; Dale O Kiesewetter; Zhantong Wang; Xiaoyuan Chen
Journal:  Biomaterials       Date:  2019-07-15       Impact factor: 12.479

2.  Catalytic Activity, Stability, and Loading Trends of Alcohol Dehydrogenase Enzyme Encapsulated in a Metal-Organic Framework.

Authors:  Josh Phipps; Hao Chen; Connor Donovan; Dylan Dominguez; Sydney Morgan; Barrett Weidman; Chenguang Fan; M Hassan Beyzavi
Journal:  ACS Appl Mater Interfaces       Date:  2020-06-01       Impact factor: 9.229

3.  Dual acting oximes designed for therapeutic decontamination of reactive organophosphates via catalytic inactivation and acetylcholinesterase reactivation.

Authors:  Jayme Cannon; Shengzhuang Tang; Kelly Yang; Racquel Harrison; Seok Ki Choi
Journal:  RSC Med Chem       Date:  2021-08-04

4.  Encapsulation of Nitrilase in Zeolitic Imidazolate Framework-90 to Improve Its Stability and Reusability.

Authors:  Hui Peng; Wenge Dong; Qiwei Chen; Haiyan Song; Hongxu Sun; Ren Li; Yanhong Chang; Hui Luo
Journal:  Appl Biochem Biotechnol       Date:  2022-04-07       Impact factor: 3.094

5.  Impact of Crystal Size and Morphology on Switchability Characteristics in Pillared-Layer Metal-Organic Framework DUT-8(Ni).

Authors:  Leila Abylgazina; Irena Senkovska; Richard Engemann; Sebastian Ehrling; Tatiana E Gorelik; Negar Kavoosi; Ute Kaiser; Stefan Kaskel
Journal:  Front Chem       Date:  2021-05-13       Impact factor: 5.221

Review 6.  Metal-Organic Framework Nanoparticle-Based Biomineralization: A New Strategy toward Cancer Treatment.

Authors:  Chengchao Chu; Min Su; Jing Zhu; Dongsheng Li; Hongwei Cheng; Xiaoyuan Chen; Gang Liu
Journal:  Theranostics       Date:  2019-05-18       Impact factor: 11.556

Review 7.  Bioengineering of Metal-organic Frameworks for Nanomedicine.

Authors:  Yuan Liu; Yanli Zhao; Xiaoyuan Chen
Journal:  Theranostics       Date:  2019-05-18       Impact factor: 11.556

8.  Determination of carbamazepine in urine and water samples using amino-functionalized metal-organic framework as sorbent.

Authors:  Mohammad Reza Rezaei Kahkha; Ali Reza Oveisi; Massoud Kaykhaii; Batool Rezaei Kahkha
Journal:  Chem Cent J       Date:  2018-06-30       Impact factor: 4.215

9.  Nanometric MIL-125-NH₂ Metal-Organic Framework as a Potential Nerve Agent Antidote Carrier.

Authors:  Sérgio M F Vilela; Pablo Salcedo-Abraira; Isabelle Colinet; Fabrice Salles; Martijn C de Koning; Marloes J A Joosen; Christian Serre; Patricia Horcajada
Journal:  Nanomaterials (Basel)       Date:  2017-10-12       Impact factor: 5.076

10.  Facile Synthesis of Enzyme-Embedded Metal-Organic Frameworks for Size-Selective Biocatalysis in Organic Solvent.

Authors:  Yangxin Wang; Ningning Zhang; Deming Tan; Zhenhui Qi; Changzhu Wu
Journal:  Front Bioeng Biotechnol       Date:  2020-07-07
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