BACKGROUND/AIMS: A limited number of studies addressed MRI-based neurodegenerative changes in subjective memory impairment (SMI). We investigated changes in white matter (WM) microstructures as well as gray matter (GM) macrostructures in subjects with SMI of high and low risk for progression. METHODS: A modeling scale (score range, 0-6) developed for prediction of SMI progression was used to divide SMI subjects (n = 46) into two groups: a high risk of progression (score ≥3; n = 19) and a low risk of progression (score ≤2; n = 27). Cross-sectional comparisons were performed using a region-of-interest-based diffusion tensor imaging (DTI) analysis, cortical thickness analysis, and hippocampal volumetry. RESULTS: The high-risk group had more microstructural disruption shown by lower fractional anisotropy in the hippocampus, parahippocampal gyrus, supramarginal gyrus, and parts of frontotemporal lobes. On the other hand, GM macrostructural changes did not differ between the groups and were not associated with modeling scale scores. CONCLUSION: SMI subjects with a high risk of progression had more WM microstructural disruption than those with a low risk, and the changes were not explained by GM atrophy. Our findings suggest that the degree of microstructural alterations in SMI may be distinctive according to the risk factors and may precede GM atrophy.
BACKGROUND/AIMS: A limited number of studies addressed MRI-based neurodegenerative changes in subjective memory impairment (SMI). We investigated changes in white matter (WM) microstructures as well as gray matter (GM) macrostructures in subjects with SMI of high and low risk for progression. METHODS: A modeling scale (score range, 0-6) developed for prediction of SMI progression was used to divide SMI subjects (n = 46) into two groups: a high risk of progression (score ≥3; n = 19) and a low risk of progression (score ≤2; n = 27). Cross-sectional comparisons were performed using a region-of-interest-based diffusion tensor imaging (DTI) analysis, cortical thickness analysis, and hippocampal volumetry. RESULTS: The high-risk group had more microstructural disruption shown by lower fractional anisotropy in the hippocampus, parahippocampal gyrus, supramarginal gyrus, and parts of frontotemporal lobes. On the other hand, GM macrostructural changes did not differ between the groups and were not associated with modeling scale scores. CONCLUSION: SMI subjects with a high risk of progression had more WM microstructural disruption than those with a low risk, and the changes were not explained by GM atrophy. Our findings suggest that the degree of microstructural alterations in SMI may be distinctive according to the risk factors and may precede GM atrophy.
Authors: Sven Haller; Marie-Louise Montandon; Cristelle Rodriguez; Valentina Garibotto; Johan Lilja; François R Herrmann; Panteleimon Giannakopoulos Journal: Front Neurosci Date: 2019-11-15 Impact factor: 4.677
Authors: Stefan J Teipel; Jan O Kuper-Smith; Claudia Bartels; Frederic Brosseron; Martina Buchmann; Katharina Buerger; Cihan Catak; Daniel Janowitz; Peter Dechent; Laura Dobisch; Birgit Ertl-Wagner; Klaus Fließbach; John-Dylan Haynes; Michael T Heneka; Ingo Kilimann; Christoph Laske; Siyao Li; Felix Menne; Coraline D Metzger; Josef Priller; Verena Pross; Alfredo Ramirez; Klaus Scheffler; Anja Schneider; Annika Spottke; Eike J Spruth; Michael Wagner; Jens Wiltfang; Steffen Wolfsgruber; Emrah Düzel; Frank Jessen; Martin Dyrba Journal: J Alzheimers Dis Date: 2019 Impact factor: 4.472
Authors: Kirsty E McAleese; Lauren Walker; Sophie Graham; Elisa L J Moya; Mary Johnson; Daniel Erskine; Sean J Colloby; Madhurima Dey; Carmen Martin-Ruiz; John-Paul Taylor; Alan J Thomas; Ian G McKeith; Charles De Carli; Johannes Attems Journal: Acta Neuropathol Date: 2017-06-21 Impact factor: 17.088