| Literature DB >> 27700080 |
Feng Peng1, Mark McLaughlin1, Yizhou Liu1, Ian Mangion1, David M Tschaen1, Yingju Xu1.
Abstract
A novel method for the oxidation of indolines to indoles is described. The method uses a Cu(I) catalyst and an organic percarbonate as the stoichiometric oxidant. The procedure was successfully applied at 0.5 kg scale in the production of a key intermediate in the synthesis of Elbasvir, which is a novel therapy for the treatment of hepatitis C virus infection.Entities:
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Year: 2016 PMID： 27700080 DOI： 10.1021/acs.joc.6b01854
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354